Evidence map›Paper›PMID 40711718›Full record

ArticleBehavior genetics2025

Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents.

Sydney Kramer, Mei-Hsin Su, Mallory Stephenson, Jill Rabinowitz, Brion Maher, Roxann Roberson-Nay, Luis F S Castro-de-Araujo, Yi Zhou, Michael C Neale, Nathan A Gillespie

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sydney KramerVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298‑0126, USA.
Mei-Hsin SuVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298‑0126, USA.
Mallory StephensonVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298‑0126, USA.
Jill RabinowitzDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, 671 Hoes Lane West, Piscataway, NJ, 08854, USA.
Brion MaherDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.
Roxann Roberson-NayDepartment of Psychiatry and Neurobehavioral Sciences, University of Virginia, 560 Ray C. Hunt Drive, Charlottesville, VA, 22903, USA.
Luis F S Castro-de-AraujoVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298‑0126, USA.
Yi ZhouVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298‑0126, USA.
Michael C NealeVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298‑0126, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298‑0126, USA. nathan.gillespie@vcuhealth.org.

Funding

Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Using transmitted and untransmitted gene networks to identify molecular pathways to substance use & misuse in genetically controlled twinsR01DA052453 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI GILLESPIE, NATHAN ALEXANDER, VLADIMIROV, VLADIMIR IVANOV · 2021 to 2024
$2.2M
An Examination of the Joint Contributions of Socioeconomic Disadvantage, Genetics, and COVID-19 on the Development of Delay Discounting and Substance Use Across AdolescenceR01DA057552 · NIDA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI JULIA W FELTON, Brion S Maher · 2022 to 2026
$1.8M
The Impact of Oral Contraceptives on Neuron-derived Exosomal miRNA Expression in the Developing BrainR21HD113953 · NICHD · UNIVERSITY OF VIRGINIA · PI ROBERSON-NAY, ROXANN, YORK, TIMOTHY P · 2024 to 2025
$452k
Quantification and Characterization of Bulk and L1CAM-Enriched Exosomal MicroRNA Cargo in Healthy Young PeopleR21MH128562 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI YAKOVLEV, VASILY · 2022 to 2023
$427k
Characterizing the Relationship Between Alcohol Consumption and Neuron-Derived Exosomal MicroRNA Cargo in an Adolescent-Young Adult Twin CohortR21AA029492 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI YAKOVLEV, VASILY · 2022 to 2023
$408k
National Institute of Child Health and Human Development R21HD113953NIAAA NIH HHS R21 AA029492NIAAA NIH HHS R21AA029492-01A1NICHD NIH HHS R21 HD113953NIDA NIH HHS 5R01DA052453-04NIDA NIH HHS R01 DA052453NIDA NIH HHS R01 DA057552NIDA NIH HHS R01DA057552NIMH NIH HHS 5T32MH-020030NIMH NIH HHS R21 MH128562NIMH NIH HHS R21MH128562NIMH NIH HHS T32 MH020030NIMH NIH HHS T32MH20030
6 · The paper itself

Abstract

Substance use has been associated with differences in adult brain morphology; however, it is unclear whether these differences precede or are a result of substance use substance use. We investigated the impact of polygenic risk scores (PRSs) for cannabis use disorder (CUD) and general substance use and substance use disorder liability (SU/SUD) on brain morphology in drug-naïve adolescents. Baseline data were used from 1874 European-descent participants (ages 9-11) comprising 222, 328 and 387 pairs of MZ twins, DZ twins, and Non-Twin Siblings, respectively, in the Adolescent Brain Cognitive Development Study. We fitted multivariate twin models to estimate the putative effects of CUD, SU/SUD, and brain region-specific PRSs. These models assessed their influence on six subcortical and two cortical phenotypes. PRS for CUD and SU/SUD were created based on GWAS conducted by Johnson et al. (Lancet Psychiatry 7:1032, 2020) and Hatoum et al. (Nat Ment Health 1:210-223, 2023), respectively. When decomposing variance in each brain region of interest (ROI), we used the corresponding ROI-specific PRS. Brain morphometry in drug-naive subjects was unrelated to CUD PRS. The variance explained in each ROI by its corresponding PRS ranged from 0.8 to 4.4%. The SU/SUD PRS showed marginally significant effects (0.2-0.4%) on cortical surface area and nucleus accumbens volume, but overall effect sizes were small. This study failed to reject the null hypothesis of no association between genetic risk for substance use and brain morphometry among baseline drug-naive adolescents. Genetic risk for CUD was not associated with brain morphometry among drug-naive adolescents, but a weak association with general addiction and substance use risk (SU/SUD) particularly in nucleus accumbens volume and total cortical surface area, was observed.

Indexed as

BrainSubstance-Related DisordersAdolescentChildFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleMarijuana AbuseMultifactorial InheritancePhenotypeRisk FactorsTwins, DizygoticBrainCerebral cortexPolygenic riskSubstance useTwin

Identifiers

PMID40711718
PMCPMC12325389

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.