Evidence map›Paper›PMID 40711688›Full record

ArticleAnnals of surgical oncology2026

Prediction of Contralateral Lymph Node Involvement during Extended Pelvic Lymph Node Dissection for Clinically Unilateral Prostate Cancer.

Masaki Shiota, Shigehiro Tsukahara, Tokiyoshi Tanegashima, Jun Mutaguchi, Shunsuke Goto, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Masaki ShiotaDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. shiota.masaki.101@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0002-3306-4858
Shigehiro TsukaharaDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tokiyoshi TanegashimaDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Jun MutaguchiDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shunsuke GotoDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Satoshi KobayashiDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takashi MatsumotoDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masatoshi EtoDepartment of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtended pelvic lymph node dissection (ePLND) plays a critical role in the accurate staging of prostate cancer; however, it is associated with increased perioperative morbidity. Refinement of the indications for ePLND through the identification of predictive factors for contralateral lymph node involvement (LNI) may contribute to minimizing overtreatment and associated complications. PATIENTS AND

methodsIn this retrospective study, we analyzed a cohort of 223 patients with clinically unilateral prostate cancer who underwent robot-assisted radical prostatectomy combined with bilateral ePLND. Tumor laterality was defined by biopsy and magnetic resonance imaging (MRI) findings. Associations between preoperative clinical factors and contralateral LNI were assessed using statistical tests.

resultsContralateral LNI was significantly associated with PSA ≥10 ng/mL (6.3% vs. 0.7%; p = 0.047) and ≥66% positive biopsy cores in the ipsilateral lobe (8.0% vs. 0%; p = 0.0037). A risk classification model combining these two factors identified a high-risk group with 13.2% incidence of contralateral LNI, compared with 0.5% in the low-risk group (p = 0.0003).

conclusionsPSA level at diagnosis and the proportion of positive biopsy cores in the ipsilateral lobe are useful predictors of contralateral LNI in clinically unilateral prostate cancer. A preoperative risk model incorporating these variables may support a tailored approach to ePLND, minimizing surgical burden without compromising diagnostic accuracy.

Indexed as

Lymph Node ExcisionLymph NodesProstatectomyProstatic NeoplasmsAgedFollow-Up StudiesHumansLymphatic MetastasisMagnetic Resonance ImagingMaleMiddle AgedPelvisPrognosisProstate-Specific AntigenRetrospective StudiesProstate-Specific AntigenContralateral lymph node involvementExtended pelvic lymph node dissectionRadical prostatectomyTumor location

Identifiers

PMID40711688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.