ReviewMedical oncology (Northwood, London, England)2025
CAR T-cell therapy in hematologic and solid malignancies: mechanisms, clinical applications, and future directions.
Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Suspension-Adapted HEK293FT Cells Enable High-Density Transfection for Efficient Lentiviral Vector Production in CAR-T Therapy.Bioengineering (Basel, Switzerland) · 2026Article
- T-Cell-Redirecting Immunotherapies in Relapsed/Refractory Mantle Cell Lymphoma: Current Evidence, Sequencing, and Future Directions.European journal of haematology · 2026Review
- Plying potency assays for immunotherapy of solid tumors.Frontiers in immunology · 2026Review
- Radiation-induced alterations in the cancer microenvironment (Review).Medicine internationalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chimeric antigen receptor (CAR) T-cell therapy represents a groundbreaking approach to treating malignancies. This immunotherapy involves genetic modification of T cells to target and eliminate tumor cells, proving effective across various cancers. Its remarkable specificity, solid tumor infiltration, and durable responses highlight its potential to revolutionize cancer treatment. By targeting specific tumor antigens, CAR-T-cell therapy minimizes off-target effects and enables personalized treatment. Six CAR-T-cell therapies have been authorized, showing exceptional effectiveness, particularly for B-cell malignancies and multiple myeloma. However, challenges such as cytokine-release syndrome, neurotoxicity, and difficulties in targeting solid tumors due to issues like unreliable antigens, hypoxic tumor cores, and immunosuppressive environments complicate its application. Addressing these requires innovative strategies to enhance CAR-T cell efficacy and reduce toxicity. This review details CAR T-cell engineering, signaling pathways, clinical successes in B-cell malignancies, challenges in solid tumors, emerging strategies, and safety management.
Indexed as
Identifiers
40711613What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.