Evidence map›Paper›PMID 40711600›Full record

ArticleMolecular genetics and genomics : MGG2025

A missense mutation in TCFL5 is associated with male infertility due to oligoasthenoteratozoospermia.

Kexin Yu, Wenchen Zhang, Yu Wang, Mingfei Xiang, Na Zheng, Jingjing Zhang, Xiaomin Zha, Zongliu Duan, Fengsong Wang, Yunxia Cao and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular genetics and genomics : MGG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kexin Yu *Reproductive Medicine Center, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.
Wenchen Zhang *School of Life Science, Anhui Medical University, Hefei, 230032, Anhui, China.
Yu Wang *Reproductive Medicine Center, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.
Mingfei XiangReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Na ZhengReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Jingjing ZhangReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Xiaomin ZhaReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Zongliu DuanReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
Fengsong WangSchool of Life Science, Anhui Medical University, Hefei, 230032, Anhui, China. fengsongw@ahmu.edu.cn.
Yunxia CaoReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China. caoyunxia6@126.com.
Fuxi ZhuReproductive Medicine Center, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China. fxzhu@ahmu.edu.cn.ORCID http://orcid.org/0000-0001-8543-9028

Funding

Key Research Program of Anhui Science and Technology Innovation Platform 202305a12020016National Natural Science Foundation of China 81972641National Natural Science Foundation of China 82071701Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province 2021zhyx-C25Scientific Research Platform Base Construction Foundation of Anhui Medical University 2023xkjT053University Natural Foundation of Anhui Educational Committee 2022AH010072
6 · The paper itself

Abstract

Oligoasthenoteratozoospermia (OAT) is a prevalent situation of male infertility partly caused by genetic defects with largely undiscovered. To further unravel the genetic etiology of OAT, we recruited cases for whole-exome sequencing (WES) to screen candidate pathogenic mutations. Here, we identified a heterozygous missense mutation in transcription factor-like 5 (TCFL5) (NM_006602.4: c.1207G > A: p.E403K) from two infertile brothers born into a non-consanguineous family. TCFL5 was previously linked to male infertility since Tcfl5

Indexed as

AsthenozoospermiaInfertility, MaleMutation, MissenseOligospermiaAdultAnimalsExome SequencingHumansMaleMicePedigreeSpermatogenesisMale infertilityOligoasthenoteratozoospermiaSpermatogenesisTCFL5Transcription factor

Identifiers

PMID40711600

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.