Trial reportLangenbeck's archives of surgery2025
The effect of preoperative oral carbohydrate intake on perioperative well-being in patients undergoing hip and lower extremity orthopedic surgery under spinal anesthesia: a randomized controlled trial.
Trial report in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of perioperative oral carbohydrate loading on postoperative outcomes in patients undergoing orthopedic surgeries: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Perioperative Interventions Based on Fasting Protocols and Carbohydrate Loading in Non-Cardiac Surgery in Older Adults: A Scoping Review.Medicina (Kaunas, Lithuania) · 2026Article
- The Influence of Preoperative Oral Carbohydrate Administration on the Perioperative Period in Children and Adolescents After Orthopedic Procedures-A Pilot Study.Healthcare (Basel, Switzerland) · 2026Article
- Nutritional status and postoperative recovery outcomes in patients undergoing orthopedic surgery.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe administration of preoperative oral carbohydrate (POC) has been shown to enhance patient well-being and expedite postoperative recovery. Nevertheless, evidence regarding its efficacy in orthopedic patients remains insufficient and warrants further investigation. This study aimed to address gaps by evaluating the effect of preoperative oral dextrose (POD) intake on perioperative well-being parameters (including thirst, hunger, anxiety, pain, nausea, and vomiting) in patients undergoing hip and lower extremity surgeries with spinal anesthesia.
methodsIn this randomized controlled trial, 70 adult patients scheduled for orthopedic surgery were assigned to either the dextrose (POD intake) group or the fasting group (routine fasting periods of 8-10 h). Perioperative subjective well-being, including measures of thirst, hunger, anxiety, pain, nausea, and vomiting, was evaluated using the Visual Analogue Scale (VAS) both preoperatively and at multiple postoperative time points (T0, T6h, and T24h). Adverse postoperative events were monitored for 24 h following surgery.
resultsSignificant improvements in perioperative thirst and pain scores were observed in the dextrose group compared to the fasting group (p = 0.041 and p = 0.003, respectively). The dextrose group consistently reported lower VAS scores for thirst, hunger, pain, and anxiety across all time points (T0, T6h, T24h) (p < 0.001). No significant differences were found between groups for nausea or vomiting (p > 0.05).
conclusionThe administration of preoperative oral carbohydrate (POC) showed no clinically significant impact on perioperative nausea or vomiting in orthopedic patients. However, it significantly improved other perioperative well-being parameters such as thirst, hunger, anxiety, and pain, highlighting its potential to enhance patient comfort and recovery outcomes.
trial registrationIranian Registry of Clinical Trials, IRCT20191017045139N2. Registered on 28 January 2024.
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