Evidence map›Paper›PMID 40711575›Full record

Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

A new olfactory rehabilitation protocol based on physiological induction of nasal airflow after total laryngectomy: the Physiological Olfactory Recovery Technique (PORT).

Lucrezia Spadera, Pietro De Luca, Pasquale Viola, Giuseppina Mirra, Alessandra Petti, Sabino Marrone, Arcangelo Menna, Emilio Avallone, Federico Maria Gioacchini, Angelo Camaioni and 2 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Post-laryngectomy videofluoroscopic assessment in relation to olfactory rehabilitation through the physiological olfactory recovery technique.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Observational
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Lucrezia SpaderaDepartment of Otolaryngology-Head and Neck Surgery, Ospedale del Mare Hospital, ASL Napoli 1 Centro, Naples, Italy.
Pietro De LucaOtolaryngology Department, Isola Tiberina - Gemelli Isola Hospital, Rome, Italy.
Pasquale ViolaDepartment of Experimental and Clinical Medicine, Unit of Audiology, Regional Centre for Cochlear Implants and ENT Diseases, Magna Graecia University, Catanzaro, Italy. pasqualeviola@unicz.it.
Giuseppina MirraDepartment of Otolaryngology-Head and Neck Surgery, Ospedale del Mare Hospital, ASL Napoli 1 Centro, Naples, Italy.
Alessandra PettiDepartment of Otolaryngology-Head and Neck Surgery, Ospedale del Mare Hospital, ASL Napoli 1 Centro, Naples, Italy.
Sabino MarroneDepartment of Otolaryngology-Head and Neck Surgery, Ospedale del Mare Hospital, ASL Napoli 1 Centro, Naples, Italy.
Arcangelo MennaDepartment of Otolaryngology-Head and Neck Surgery, Ospedale del Mare Hospital, ASL Napoli 1 Centro, Naples, Italy.
Emilio AvalloneKlinik Und Poliklinik Für Hals, Nasen- Und Ohrenheilkunde, Medizinische Hochschule Hannover, Hannover, Germany.
Federico Maria GioacchiniDepartment of Clinical and Molecular Sciences, ENT Unit, Polytechnic University of Marche, Ancona, Italy.
Angelo CamaioniHead and Neck Department, Nostra Signora Della Mercede Clinic, Rome, Italy.
Giuseppe TortorielloDepartment of Otolaryngology-Head and Neck Surgery, AORN Ospedali Dei Colli Monaldi - Cotugno - C.T.O. Hospital, Naples, Italy.
Giuseppe ChiarellaDepartment of Experimental and Clinical Medicine, Unit of Audiology, Regional Centre for Cochlear Implants and ENT Diseases, Magna Graecia University, Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate whether a new nasal airflow induction manoeuvre based on the Physiological Olfactory Recovery Technique (PORT) could be an effective alternative to current techniques for restoring olfactory function in laryngectomised patients.

methodsThis is a prospective observational cohort study, including patients who underwent total laryngectomy (TL) and primary tracheoesophageal puncture (TEP) placement for advanced laryngeal cancer (LC). To restore olfactory function, all patients underwent 10 sessions of PORT rehabilitation training at least 2 months after surgery. Outcomes in terms of olfactory acuity, subjective symptoms, and HRQoL were assessed using olfactometry and two structured questionnaires (the Chemosensory Complaints Score and University of Washington Quality of Life version 4), before and after treatment, and after a 6-month follow-up.

resultsTwenty laryngectomised patients (15 men and 5 women, with a mean age of 65 ± 8 years) were enrolled in the study. These patients underwent proprioceptive training with a speech and language therapist and learnt the PORT method. Seventeen patients who were unable to smell before treatment became able to smell, while the remaining three patients, who were hyposmic at the beginning of treatment, became normosmic by the end. Following 10 sessions of the rehabilitation programme, all 20 patients demonstrated significant improvements across all outcome measures. These results were maintained in the long term.

conclusionFor laryngectomised patients, PORT is an effective alternative to the Nasal Air Flow Induction Maneuver (NAIM) for olfactory rehabilitation. This technique enabled all rehabilitated patients to regain their daily 'olfactory gesture' physiologically.

Indexed as

Laryngeal NeoplasmsLaryngectomyOlfaction DisordersAgedCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedOlfactory TrainingProspective StudiesQuality of LifeRecovery of FunctionSmellSurveys and QuestionnairesLaryngectomyOlfactionOlfactory rehabilitationVoice prosthesis

Identifiers

PMID40711575

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.