Anxiety and depressive disorders in the offspring of mothers with perinatal depressive disorders.

Biruk Shalmeno Tusa, Rosa Alati, Getinet Ayano, Kim Betts, Berihun Dachew

Abstract read

In one paragraph

Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Effectiveness of a family-oriented intervention for children of mentally ill parents on children's mental health and health-related quality of life: a prospective, rater-blinded, cluster-randomized controlled multicenter trial.Child and adolescent psychiatry and mental health · 2026
Article
Novel anxiolytic-antidepressant combinations TF-1 and TF-2 and their intervention mechanisms in a mouse model of comorbid anxiety and depression (CAD).Frontiers in pharmacology · 2026
Article
Perinatal HPA axis regulation and offspring neuropsychiatric development: mechanisms, developmental trajectories, and clinical implications.Frontiers in endocrinology · 2026
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Biruk Shalmeno TusaSchool of Population Health, Curtin University, Kent Street, Bentley, Perth, Western Australia, 6102, Australia. b.tusa@postgrad.curtin.edu.au.

Rosa AlatiSchool of Population Health, Curtin University, Kent Street, Bentley, Perth, Western Australia, 6102, Australia.

Getinet AyanoSchool of Population Health, Curtin University, Kent Street, Bentley, Perth, Western Australia, 6102, Australia.

Kim BettsSchool of Population Health, Curtin University, Kent Street, Bentley, Perth, Western Australia, 6102, Australia.

Berihun DachewSchool of Population Health, Curtin University, Kent Street, Bentley, Perth, Western Australia, 6102, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal perinatal depression has been linked to increased risk of anxiety and depression in offspring. However, many studies are limited by small sample sizes, self-reported data, and insufficient adjustment for confounders, including comorbid maternal anxiety disorders. Using a large linked administrative health dataset from New South Wales, Australia, this study aimed to examine the risk of anxiety and depressive disorders among offspring of mothers with perinatal depressive disorders, with diagnoses identified using the International Classification of Diseases, Tenth Revision, Australian Modification (ICD-10 AM) codes. Associations were assessed using generalized linear model and propensity score matching. Offspring of mothers with perinatal depressive disorders had a 56% higher risk of depressive disorders (RR = 1.56, 95% CI = 1.05-2.29), though this was not observed after matching (RR = 1.42, 95% CI = 0.93-2.18). Maternal perinatal depressive disorders were associated with a higher risk of anxiety disorders (RR = 2.10, 95% CI = 1.78-2.48), which remained significant after propensity score matching (RR = 1.90, 95% CI = 1.59-2.28). Offspring of mothers with comorbid perinatal depressive and anxiety disorders had a 2.36-fold higher risk of depressive disorders (RR = 2.36, 95% CI = 1.21-4.63), a 2.56-fold higher risk of anxiety disorders (RR = 2.56, 95% CI = 1.89-3.48), and a 3.37-fold higher risk of comorbid depressive and anxiety disorders (RR = 3.37, 95% CI = 1.54-7.36). These findings highlight the increased risk of depressive and anxiety disorders in offspring of mothers with perinatal depressive disorders, with stronger associations observed when maternal depression coexists with anxiety. The results underscore the need for early detection and targeted interventions for maternal perinatal depressive and anxiety disorders to reduce adverse mental health outcomes in offspring.

Indexed as

Anxiety DisordersChild of Impaired ParentsDepressive DisorderMothersPregnancy ComplicationsAdolescentAdultChildChild, PreschoolComorbidityFemaleHumansMaleNew South WalesPregnancyYoung AdultAnxiety disordersDepressive disordersMaternal perinatal depressive disordersOffspring

Identifiers

PMID40711570

DOI10.1007/s00787-025-02803-9

PMCPMC12743092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.