Observational studyPediatric nephrology (Berlin, Germany)2025
Efficacy and safety of telitacicept in IgA nephropathy and IgA vasculitis nephropathy in adolescents: a case series.
Observational study in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immune-mediated renal injury and cardiometabolic risk in IgA nephropathy: clinical evidence on telitacicept from a scoping review.Frontiers in nutrition · 2026Pooled it
- Clinical value of repeat kidney biopsy in pediatric IgA vasculitis nephritis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Efficacy and safety of telitacicept in IgA vasculitis nephritis: a single-center retrospective study.European journal of pediatrics · 2026Article
- Short-term changes in clinical parameters associated with telitacicept in pediatric IgA nephropathy: a single-center self-controlled observational study.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundIgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN) are among the most common glomerulopathies in adolescents, yet treatment options remain limited. Telitacicept (TACI), a dual-target fusion protein, has shown therapeutic potential in adult patients. This study aimed to evaluate the efficacy and safety of telitacicept in adolescents with IgAN and IgAVN.
methodsThis retrospective observational study included 15 adolescent patients (11 with IgAN and 4 with IgAVN) who received telitacicept between January 2023 and January 2025. Patients received weekly subcutaneous injections of 80 mg or 160 mg. The primary efficacy outcome was proteinuria from baseline to follow-up. Secondary outcomes included changes in eGFR, serum albumin, and hemoglobin.
resultsThe median age of the patients was 16.91 years. After TACI treatment, the median proteinuria decreased from 2.0 g/day at baseline to 1.0 g/day at month 3 (P = 0.074) and further to 0.5 g/day at month 12 (P = 0.015), corresponding to median reductions of 31.2% and 59.0%, respectively. Median eGFR remained stable, showing an 1.1% increase at month 12 (P = 0.912). At month 12, serum albumin and hemoglobin increased by 5.6 g/L (5.8%) and 12.5 g/L (10.6%), respectively. Subgroup analyses showed consistent proteinuria reduction across baseline characteristics. Most patients tolerated telitacicept well, with no serious adverse events or treatment discontinuations reported.
conclusionsTelitacicept appeared to be well-tolerated and was associated with substantial reductions in proteinuria in adolescent patients with IgAN and IgAVN. Larger studies are needed to validate these findings.
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Registered trials
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