Evidence map›Paper›PMID 40711521›Full record

ArticleIrish journal of medical science2025

Subtype-specific expression of lncRNAs SNHG12 and HAGLR as non-invasive biomarkers for diagnosis and prognosis in breast cancer.

Mohammad Farid Mohammadi, Arezoo Farhadi, Maedeh Ganji, Morteza Gholami, Yaser Mansoori, Rasoul Abdollahzadeh, Pouria Mohammadi, Javad Behroozi

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Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Mohammad Farid Mohammadi *Department of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Arezoo Farhadi *Department of Genetics and Molecular Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Maedeh GanjiDena Genetics Laboratory, Tehran, Iran.
Morteza GholamiMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Yaser MansooriDepartment of Medical Genetics, Fasa University of Medical Sciences, Fasa, Iran.
Rasoul AbdollahzadehDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Pouria MohammadiFaculty of Medical Sciences, Department of Medical Genetics, Tarbiat Modares University, Tehran, Iran. pouria.mohammaditmu@gmail.com.
Javad BehrooziCancer Epidemiology Research Center, Aja University of Medical Sciences, Tehran, Iran. jvdbehroozi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong non-coding RNAs (lncRNAs) SNHG12 and HAGLR have different molecular functions in breast cancer (BC). We investigated their expression profiles in different subtypes of BC, breast tissues, and plasma in association with clinicopathological and reproductive conditions.

methodsThe expression levels of SNHG12 and HAGLR were detected by qRT-PCR in 150 BC tumors including 35 triple-negative BC (TNBC), 30 HER2-enriched, 30 luminal B, and 55 luminal A and their corresponding tumor-adjacent apparently normal (TAN), as well as in truly normal (TN) tissues and plasma samples of 150 cancer-free women.

resultsThe SNHG12 and HAGLR upregulated in tumor tissues compared to TAN and TN, as well as in TAN relative to TN in all subtypes. The increased level of SNHG12 was observed only in TNBC patients with larger tumor sizes and positive status of lymph node metastasis (LNM

conclusionsOur results showed the BC subtype-specific expression profiles of SNHG12 and HAGLR and represent these lncRNAs as useful diagnostic and prognostic biomarkers for BC.

Indexed as

Biomarkers, TumorBreast NeoplasmsRNA, Long NoncodingTriple Negative Breast NeoplasmsAdultAgedFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMiddle AgedPrognosisBiomarkers, TumorRNA, Long NoncodingSNHG12 long non-coding RNA, humanBreast cancerDiagnostic biomarkersGene expression profilingHAGLRLncRNAsSNHG12

Identifiers

PMID40711521

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