Evidence map›Paper›PMID 40711415›Full record

Observational studyDeutsches Arzteblatt international2025

Triage of Stable Patients With Suspected Acute Myocardial Infarction and Left Bundle Branch Block: A Multicenter, Propensity Score-Matched Analysis.

Sascha Macherey-Meyer, Sebastian Heyne, Max Maria Meertens, Karl Finke, Victor Mauri, Johannes Terporten, Ingo Ahrens, Frank Michael Baer, Frank Eberhardt, Marc Horlitz and 7 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Deutsches Arzteblatt international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sascha Macherey-MeyerUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany; Cardiology III Angiology, Department of Cardiology, University Hospital, University of Mainz, Mainz, Germany; Department of Cardiology and Internal Intensive Care Medicine, Augustinerinnen Teaching Hospital, Cologne, Germany; Department of Medicine and Cardio-Diabetes Center Cologne, St. Antonius Hospital, Cologne, Germany; Cardiology and Internal Intensive Care Medicine, Protestant Hospital Köln-Kalk, Cologne, Germany; Department of Cardiology, Electrophysiology, and Rhythmology, Porz am Rhein Hospital gGmbH, Cologne, Germany; Internal Medicine III - Cardiology, St. Vinzenz Hospital, Cologne, Germany; Department of Medicine II, Cologne Municipal Hospitals gGmbH, Merheim Hospital, Cologne, Germany; Institute for Medical Statistics and Bioinformatics, Medical Faculty and University Hospital, University of Cologne, Germany.
Sebastian Heyne
Max Maria Meertens
Karl Finke
Victor Mauri
Johannes Terporten
Ingo Ahrens
Frank Michael Baer
Frank Eberhardt
Marc Horlitz
Jan-Malte Sinning
Axel Meissner
Benjamin Rosswinkel
Stephan Baldus
Christoph Adler
Samuel Lee
KIM e.V.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA pragmatic immediate invasive strategy is recommended in patients with ischemic symptoms and suspected left bundle branch block acute myocardial infarction (LBBB-AMI). It is important to identify patients with LBBB-AMI who do not need to be treated with the same strategy as those with ST-segment elevation myocardial infarction (STEMI). In this study, we aimed to compare the outcome of stable but symptomatic patients with suspected LBBB-AMI with that of matched STEMI patients.

methodsAll consecutive patients who were referred for percu - taneous coronary intervention (PCI) in a metropolitan, multicenter STEMI network in Germany were analyzed and stratified according to their ECG findings (STEMI or LBBB). Propensity score matching (PSM) and adjusted analyses were performed.

results4563 patients were included: 4219 (92.5%) with STEMI, and 344 (7.5%) with LBBB-AMI. After the identification of stable patients and PSM (n = 187 LBBB-AMI, n = 557 STEMI), the odds ratios for LBBB-AMI patients were 1.61 (95% confidence interval, [0.78; 3.32]) for in-hospital mortality, 0.56 [0.32; 0.91] for culprit lesion, and 2.18 [1.24; 3.84] for impaired patency of infarct-related artery after PCI. The median peak creatine kinase level was 1075 U/L in the STEMI patients and 478 U/L in the LBBB-AMI patients (estimated difference: -153 U/L [-504; 196]). Approximately, 70% of the LBBB-AMI patients had a culprit lesion in combination with myocardial necrosis implying acute stenosis.

conclusionApproximately, seven of ten symptomatic LBBB-AMI patients had acute culprit lesions requiring timely PCI. The findings support routine emergency coronary angiography in these patients. Future prospective trials should address more selective triage.

Indexed as

Bundle-Branch BlockMyocardial InfarctionPercutaneous Coronary InterventionTriageAgedComorbidityElectrocardiographyFemaleGermanyHospital MortalityHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesRisk Factors

Identifiers

PMID40711415
PMCPMC12620899

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.