Evidence map›Paper›PMID 40711376›Full record

Trial reportMolecular nutrition & food research2025

Effect of the Consumption of Lean Red Meat from Beef (Pirenaica Breed) Versus Lean White Meat (Chicken) on the Gut Microbiota: A Randomized Cross-Over Study in Healthy Young Adults.

Isabel Rueda-De Torre, Julio Plaza-Diaz, María L Miguel-Berges, Angel Gil, Laura Grasa, Luis Mariano Esteban, Sergio Sabroso-Lasa, María M Campo, Pilar Santolaria, Luis A Moreno and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Molecular nutrition & food research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Isabel Rueda-De TorreGENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, Universidad de Zaragoza, Zaragoza, Spain.
Julio Plaza-DiazCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain.ORCID 0000-0002-5171-9408
María L Miguel-BergesGENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, Universidad de Zaragoza, Zaragoza, Spain.ORCID 0000-0002-2411-9538
Angel GilCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Madrid, Spain.
Laura GrasaInstituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain.ORCID 0000-0002-5306-9365
Luis Mariano EstebanEscuela Politécnica de La Almunia, Universidad de Zaragoza, Zaragoza, Spain.
Sergio Sabroso-LasaGenetic and Molecular Epidemiology Group (GMEG), Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
María M CampoInstituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza-CITA, Zaragoza, Spain.
Pilar SantolariaDepartamento de Producción Animal y Ciencia de los Alimentos, Universidad de Zaragoza, Zaragoza, Spain.
Luis A MorenoGENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, Universidad de Zaragoza, Zaragoza, Spain.
Alba M Santaliestra-PasíasGENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, Universidad de Zaragoza, Zaragoza, Spain.

Funding

European Regional Development Fund
6 · The paper itself

Abstract

Limited evidence exists regarding the impact of meat consumption on the human gut microbiota, with factors such as animal source, production system, and cooking methods often overlooked. This study evaluates the effect of Pirenaica breed beef or conventional chicken-based diets on the gut microbiota of healthy adults. A randomized cross-over controlled trial with two 8-week periods, separated by a 5-week washout, is carried out. Participants consume either Pirenaica breed beef or chicken three times per week with their diet. Stool samples are collected at the beginning and end of each period. Gut microbiota is analyzed via amplification and sequencing of V3-V4 regions of 16S rRNA. Alpha diversity and relative abundances at phylum and genus levels are calculated. Sixteen participants are included (mean age 20.12 ± 2.36 years). Both diets induce modest changes in microbial composition, with no significant differences between groups. At the phylum level, Bacillota increased, while Synergistota, Chloroflexota, and Pseudomonadota decreased. Alpha diversity parameters declined significantly after the chicken-based diet, although overall reduction in microbial diversity was observed across both interventions. The consumption of lean red meat or lean white meat as part of habitual diet produces similar effects on the gut microbiota.

Indexed as

DietGastrointestinal MicrobiomeRed MeatAdultAnimalsCattleChickensCross-Over StudiesFecesFemaleHumansMaleMeatRNA, Ribosomal, 16SYoung AdultRNA, Ribosomal, 16Sdiet interventiongut microbiotared meatwhite meatyoung adults

Identifiers

PMID40711376
PMCPMC12581753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.