Evidence map›Paper›PMID 40711300›Full record

ArticleVeterinary sciences2025

Levamisole as a Strategy Against Bacteria from Canine Otitis Externa: An In Vitro Evaluation.

Rodrigo F M Guedes, Ana C C F Soares, Francisco I F Gomes, Alyne S Freitas, Vinicius C Pereira, Rossana A Cordeiro, Marcos F G Rocha, José J C Sidrim, Giovanna R Barbosa, Glaucia M M Guedes and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rodrigo F M GuedesCourse of Veterinary Medicine, Education, Sciencies and Technology Center of the Inhamuns Region, State University of Ceará, Tauá 63660-000, CE, Brazil.
Ana C C F SoaresCourse of Veterinary Medicine, University of Fortaleza, Fortaleza 60811-905, CE, Brazil.
Francisco I F GomesGroup of Applied Medical Microbiology, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.
Alyne S FreitasGroup of Applied Medical Microbiology, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.
Vinicius C PereiraGroup of Applied Medical Microbiology, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.
Rossana A CordeiroLaboratory of Infectious Bioagents, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.
Marcos F G RochaPost-Graduate Program in Veterinary Sciences, College of Veterinary, State University of Ceará, Fortaleza 60714-903, CE, Brazil.
José J C SidrimSpecialized Medical Mycology Center, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.
Giovanna R BarbosaGroup of Applied Medical Microbiology, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.
Glaucia M M GuedesGroup of Applied Medical Microbiology, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.
Debora S C M Castelo-BrancoGroup of Applied Medical Microbiology, Post-Graduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza 60420-270, CE, Brazil.ORCID 0000-0002-6045-2354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canine otitis externa is a prevalent condition, and inadequate treatment may favor the emergence of multidrug-resistant microorganisms. Drug repurposing provides an alternative approach for the management of this disease. Thus, this study aimed at assessing the antimicrobial and antibiofilm properties of levamisole against bacterial strains recovered from dogs with otitis externa as well as its influence on biofilm growth dynamics during 120 h. A total of 50 clinical bacterial isolates were subjected to analysis. Planktonic bacterial susceptibility to levamisole was assessed by broth microdilution to determine the minimum inhibitory concentration (MIC), the lowest concentration that completely inhibits bacterial growth. The activity against mature biofilms was assessed by determining the minimum biofilm eradication concentration (MBEC). The effect of levamisole on biofilm formation was evaluated at the MIC and at two subinhibitory concentrations, with daily readings recorded at 48, 72, 96, and 120 h. MICs of levamisole ranged from 0.58 to 2.34 mg/mL. Levamisole reduced the biomass of mature biofilms (

Indexed as

bacteriabiofilmscanine external otitislevamisole

Identifiers

PMID40711300
PMCPMC12299382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.