Evidence map›Paper›PMID 40711266›Full record

ArticleVeterinary sciences2025

Isolation and Pathogenicity of an Emerging Highly Virulent CSFV 2.1c Strain in South China.

Xiaopeng Gao, Yu Wu, Yi Song, Feibao Huang, Limiao Lin, Haishen Zhao, Bohua Ren, Qunhui Li, Lang Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaopeng GaoKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510000, China.
Yu WuWen's Food Group, Yunfu 527400, China.
Yi SongKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510000, China.
Feibao HuangKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510000, China.
Limiao LinYunfu Branch of Guangdong Provincial Laboratory of Modern Agricultural Science and Technology, Lingnan, 527400, China.
Haishen ZhaoYunfu Branch of Guangdong Provincial Laboratory of Modern Agricultural Science and Technology, Lingnan, 527400, China.
Bohua RenYunfu Branch of Guangdong Provincial Laboratory of Modern Agricultural Science and Technology, Lingnan, 527400, China.
Qunhui LiWen's Food Group, Yunfu 527400, China.
Lang GongKey Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510000, China.

Funding

the open competition program of top ten critical priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province（2024KJ14）. 2024KJ14
6 · The paper itself

Abstract

Classical swine fever (CSF) is an infectious disease caused by classical swine fever virus (CSFV), which is endemic in many areas of China, causing serious economic losses to pig farms. Currently, 2.1 subgenotype strains are predominantly prevalent in China. Although abundant information is available on 2.1 subgenotype isolates, limited data are available on pathogenicity analysis. In this study, a CSFV strain was isolated from a pig farm in Guangdong Province, China. Whole genome sequencing showed that the strain had a genome length of 12,296 bp, and it was named GD-2024. Based on genetic evolutionary analysis, the strain was categorized into subgenotype 2.1c, and the nucleotide and amino acid homology of the strain with the representative strains of each subgenotype was in the range of 83.1-97.6% and 90.8-99.4%, respectively. Further mutation analysis revealed that the strain had three nucleotide site mutations in the 5'UTR and 3'UTR regions and two amino acid site mutations in the E2 region. The clinical pathogenicity of this strain was investigated. Infection with GD-2024 led to persistent fever and high viremia in pigs as well as inflammatory damage in multivisceral tissues. The mortality rate of infected pigs reached as high as 60%, contradicting the currently reported virulence of 2.1 strains. In summary, we have isolated and reported a subgenotype 2.1c strain with high virulence. Its genomic variation provides a basis for further analysis of virulence determinants and serves as a clinical reference and guide for the prevention and control of CSF.

Indexed as

classical swine fevergenomemutationpathogenicityvirulence

Identifiers

PMID40711266
PMCPMC12301022

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