Evidence map›Paper›PMID 40711188›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Receptor-Mediated SPION Labeling of CD4

Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu PingShu Chien Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.
Songyue HanShu Chien Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.ORCID 0009-0009-7072-5836
Brock HowertonShu Chien Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.
Francesc MartiDepartment of Surgery, Transplant Division, University of Kentucky, Lexington, KY 40506, USA.
Jake WeeksShu Chien Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.ORCID 0009-0001-2645-9034
Roberto GedalyDepartment of Surgery, Transplant Division, University of Kentucky, Lexington, KY 40506, USA.
Reuben AdatorwovorDepartment of Biostatistics, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-0503-3173
Fanny ChapelinShu Chien Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0001-9340-743X

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
Equipment upgrade for 7T Small Animal MRI systemS10OD032343 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIU, THOMAS T · 2022 to 2022
$600k
Magnetic resonance imaging methods to track Treg distribution and homing for clinical applicationsR03EB035177 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAPELIN, FANNY · 2024 to 2025
$246k
NCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA177558NIBIB NIH HHS R03 EB035177NIH HHS 1R03EB035177-01NIH HHS 3R03EB035177-01S1NIH HHS 5KL2TR001444-10NIH HHS 5R03EB035177-02NIH HHS 5UL1TR001998-06NIH HHS S10 OD032343
6 · The paper itself

Abstract

Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change. In this study, we explored CD4-Superparamagnetic iron oxide nanoparticles (SPION), which is commonly used in magnetic cell sorting, as a potential receptor-mediated, specific CD4

Indexed as

CD4+ T cellsimmunomodulationmagnetic-activated cell sortingMRISPIONtransplantation

Identifiers

PMID40711188
PMCPMC12299031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.