Evidence map›Paper›PMID 40711145›Full record

ArticleToxins2025

Associations Between Uraemic Toxins and Gut Microbiota in Adults Initiating Peritoneal Dialysis.

Philippa James, Jordan Stanford, Ojas V A Dixit, Mary Ann Nicdao, Brett McWhinney, Kamal Sud, Michele Ryan, Scott Read, Golo Ahlenstiel, Kelly Lambert and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. CD4Frontiers in cellular and infection microbiology · 2026
    Article
  7. Observational
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Philippa JamesSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.
Jordan StanfordSchool of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.
Ojas V A DixitSchool of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia.
Mary Ann NicdaoWestern Renal Services, Western Sydney and Nepean Blue Mountains Local Health Districts, Sydney, NSW 2750, Australia.
Brett McWhinneyAnalytical Chemistry Unit, Chemical Pathology, Pathology Queensland, Brisbane, QLD 4029, Australia.
Kamal SudWestern Renal Services, Western Sydney and Nepean Blue Mountains Local Health Districts, Sydney, NSW 2750, Australia.ORCID 0000-0001-7648-007X
Michele RyanWestern Renal Services, Western Sydney and Nepean Blue Mountains Local Health Districts, Sydney, NSW 2750, Australia.
Scott ReadSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.
Golo AhlenstielSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.
Kelly LambertHealth Innovations, University of Wollongong, Wollongong, NSW 2500, Australia.ORCID 0000-0001-5935-7328
Claire O'BrienFaculty of Science and Technology, University of Canberra, Canberra, ACT 2617, Australia.
Katrina ChauSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Declining kidney function contributes to the accumulation of uraemic toxins produced by gut microbiota, leading to the uraemic syndrome. This study aimed to identify associations between uraemic toxins, diet quality, symptoms and the gut microbiota in individuals initiating peritoneal dialysis. A cross-sectional analysis of baseline data from participants in a longitudinal study was conducted. Symptom scores using the Integrated Palliative Care Outcomes Scale-Renal were recorded. Plasma p-Cresyl sulfate, indoxyl sulfate and trimethylamine N-oxide were measured using liquid chromatography-mass spectrometry. Gut microbiota was determined using 16S rRNA sequencing. Multivariate linear models examined associations across the cohort. Data from 43 participants (mean age 61 ± 13 years; 70% male; median eGFR 7 mL/min/1.73 m

Indexed as

Gastrointestinal MicrobiomePeritoneal DialysisUremiaUremic ToxinsAgedBacteriaCresolsCross-Sectional StudiesFemaleHumansIndicanLongitudinal StudiesMaleMethylaminesMiddle AgedSulfuric Acid Esters4-cresol sulfateCresolsIndicanMethylaminesSulfuric Acid EsterstrimethyloxamineUremic Toxinschronic kidney diseasediet therapygut microbiomekidney failureperitoneal dialysisuraemic toxin

Identifiers

PMID40711145
PMCPMC12300580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.