Evidence map›Paper›PMID 40711143›Full record

ArticleToxins2025

Camila R Ferraz, Marília F Manchope, Mariana M Bertozzi, Telma Saraiva-Santos, Ketlem C Andrade, Anelise Franciosi, Tiago H Zaninelli, Julia Bagatim-Souza, Sergio M Borghi, Denise M Cândido and 4 more

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Camila R FerrazDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0003-4550-0773
Marília F ManchopeDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0003-2882-6536
Mariana M BertozziDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0002-0551-4313
Telma Saraiva-SantosDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Ketlem C AndradeDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Anelise FranciosiDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0002-4643-2322
Tiago H ZaninelliDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0001-7233-477X
Julia Bagatim-SouzaDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.
Sergio M BorghiDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0002-6978-7505
Denise M CândidoArthropod Laboratory, Butantan Institute, São Paulo 05503-900, São Paulo, Brazil.
Thiago M CunhaCenter of Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, São Paulo, Brazil.
Rubia CasagrandeDepartment of Pharmaceutical Sciences, Centre of Health Sciences, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0002-2296-1668
Fábio H KwasniewskiDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0002-0282-9096
Waldiceu A VerriDepartment of Immunology, Parasitology and General Pathology, Londrina State University, Londrina 86057-970, Paraná, Brazil.ORCID 0000-0003-2756-9283

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior finance code 001Fundação Araucária PRONEX grant agreement 014/2017, protocol 46.843Fundação Nacional de Desenvolvimento do Ensino Superior Particular n/aGoverno do Estado do Paraná, Conselho Paranaense de Ciência e Tecnologia, e Secretaria de Es-tado da Ciência, Tecnologia, e Ensino Superior dotação orçamentária #4560.19.571.06.6153; eprotocolo 21.234.745-0National Council for Scientific and Technological Development 427946/2018-2; 405027/2021-4; 309633/2021-4; 307689/2022-0; 404445/2024-1; 444591/2024-9; 405848/2025-0
6 · The paper itself

Abstract

For centuries, researchers have been fascinated by the composition of scorpion venom and its local and systemic effects on humans. During a sting, scorpions inject peptides and proteins that can affect immune cells and neurons. While the immune and nervous systems have been studied independently in the context of scorpion stings, here we reveal part of the mechanism by which

Indexed as

CytokinesHyperalgesiaNociceptionScorpion StingsScorpion VenomsTRPV Cation ChannelsAnimalsAnimals, PoisonousGanglia, SpinalMacrophagesMaleMiceMice, Inbred C57BLNeutrophilsScorpionsCytokinesScorpion VenomsTRPV1 protein, mouseTRPV Cation ChannelshyperalgesiaIL-1βneuroinflammationNFκBpainTityus serrulatusTNF-α

Identifiers

PMID40711143
PMCPMC12300514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.