Evidence map›Paper›PMID 40711058›Full record

ArticleTropical medicine and infectious disease2025

Differential Emodepside Efficacy in Drug-Resistant and Drug-Susceptible

Catherine A Jackson, Elise L McKean, John M Hawdon

Abstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Catherine A JacksonDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.ORCID 0009-0001-0010-6222
Elise L McKeanDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.ORCID 0009-0005-5269-6649
John M HawdonDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-6164-1413

Funding

Dissecting the mechanism of pyrantel resistance in hookwormR21AI166279 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI HAWDON, JOHN M, O'HALLORAN, DAMIEN M · 2023 to 2024
$444k
NIAID NIH HHS R21 AI166279NIH HHS 1R21AI166279-01
6 · The paper itself

Abstract

Multi-anthelmintic resistance in hookworms poses a significant challenge to both human and veterinary health, underscoring the need for novel treatment strategies. In this study, we evaluated the in vitro efficacy of three anthelmintics-pyrantel, ivermectin, and emodepside-against L3 larvae of drug-susceptible (WMD) and triple-anthelmintic-resistant (BCR) isolates of

Indexed as

Ancylostoma caninumBK channelemodepsidehookworm infectionL3multidrug resistanceSLO-1 channel

Identifiers

PMID40711058
PMCPMC12297997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.