Evidence map›Paper›PMID 40711054›Full record

ArticleTropical medicine and infectious disease2025

Evaluation of Social and Clinical Factors Associated with Adverse Drug Reactions Among Children with Drug-Resistant Tuberculosis in Pakistan.

Muhammad Soaib Said, Razia Fatima, Rabbiya Ahmad, Mahmood Basil A Al Rawi, Faheem Jan, Sobia Faisal, Irfanullah Khan, Amer Hayat Khan

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Article in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Muhammad Soaib SaidDiscipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Gelugor 11700, Malaysia.
Razia FatimaThe Common Management Unit for TB HIV AIDS and Malaria, Ministry of National Health Services, Regulation and Coordination, Islamabad 44000, Pakistan.
Rabbiya AhmadDiscipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Gelugor 11700, Malaysia.
Mahmood Basil A Al RawiDiscipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Gelugor 11700, Malaysia.
Faheem JanThe Common Management Unit for TB HIV AIDS and Malaria, Ministry of National Health Services, Regulation and Coordination, Islamabad 44000, Pakistan.
Sobia FaisalThe Common Management Unit for TB HIV AIDS and Malaria, Ministry of National Health Services, Regulation and Coordination, Islamabad 44000, Pakistan.
Irfanullah KhanDepartment of Integrative Biology, Oklahoma State University, 420 Life Sciences West, Stillwater, OK 74078, USA.
Amer Hayat KhanDiscipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Gelugor 11700, Malaysia.ORCID 0000-0003-4802-6181

Funding

King Saud University RSP2024R378
6 · The paper itself

Abstract

(1) Background: The occurrence, intensity, and characteristics of adverse drug reactions (ADRs) caused by anti-tuberculosis (TB) drugs have consistently been a subject of worry. There is a lack of published research from Pakistan regarding the negative effects of anti-TB treatment on children, specifically about ADRs. In this study, we aimed to investigate the ADR associated with anti-DR-TB treatment in children. (2) Methods: A prospective longitudinal study was conducted in the multicenter setting of Khyber Pakhtunkhwa, Pakistan. A total of 450 TB children in multicenter hospitals under ATT were assessed for ADRs. Naranjo Causality Assessment and Hartwig's Severity Assessment Scale were used to evaluate the causality and severity. (3) Results: A total of 300 (66.66%) ADRs were reported in 450 people with DRTB. Anemia was the most frequently observed ADR (37.6%) followed by nausea and vomiting (18.6%). On multivariate analysis, the independent variables that had a statistically significant positive association with ADRs were participants aged, 5-14 years (AOR, 0.3 (0.1-0.5),

Indexed as

adverse drug reactionschildrenrisk factors

Identifiers

PMID40711054
PMCPMC12299254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.