Exposure to Metal Mixtures and Metabolic Syndrome in Residents Living near an Abandoned Lead-Zinc Mine: A Cross-Sectional Study.

Information regarding the impact of polymetallic exposure on metabolic syndrome (MetS) among residents living near abandoned Pb-Zn mines is limited. Our objective was to investigate the impact of co-exposure to metal mixtures on the prevalence of MetS among residents. ICP-MS was used to measure the levels of 24 metals in the urine of 1744 participants, including 723 participants living near abandoned Pb-Zn mines, labeled as exposed area, and 1021 participants from other towns, labeled as reference area in the same city. Multivariable generalized linear regression, adaptive LASSO penalized regression, and BKMR were used to assess the associations between metals and MetS. The levels of eleven metals were higher, while those of nine metals were lower in the exposed area than those in the reference area. Mg, Cd, Ti, TI, Zn, Rb, and Pb were selected as important MetS predictors using LASSO regression. In exposed area, urinary Zn and TI were positively associated with MetS, whereas Mg was negatively associated with MetS. In the reference area, urinary Zn was positively associated with MetS, whereas Mg and Ti were negatively associated with MetS. The BKMR model indicates a statistically significant positive overall effect of the seven metal mixtures on MetS in the exposed area. Polymetallic exposure was positively associated with MetS risk in the abandoned Pb-Zn mining areas, suggesting that excessive Zn and TI may be associated with a higher MetS risk among residents living near abandoned Pb-Zn mines.