Evidence map›Paper›PMID 40710916›Full record

ReviewNeurology international2025

The Central Variant of Posterior Reversible Encephalopathy Syndrome: A Systematic Review and Meta-Analysis.

Bahadar S Srichawla, Maria A Garcia-Dominguez, Brian Silver

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PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bahadar S SrichawlaDepartment of Neurology, University of Massachusetts Chan Medical School, 55 Lake Ave N, Worcester, MA 01655, USA.
Maria A Garcia-DominguezDepartment of Neurology, University of Massachusetts Chan Medical School, 55 Lake Ave N, Worcester, MA 01655, USA.
Brian SilverDepartment of Neurology, University of Massachusetts Chan Medical School, 55 Lake Ave N, Worcester, MA 01655, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe central variant of posterior reversible encephalopathy syndrome (cvPRES) is an atypical subtype of PRES. Although no unifying definitions exists, it is most often characterized by vasogenic edema involving "central" structures, such as the brainstem, subcortical nuclei, and spinal cord, with relative sparing of the parieto-occipital lobes.

methodsThis systematic review and meta-analysis followed the PRISMA guidelines and was pre-registered on PROSPERO [CRD42023483806]. Both the Joanna Briggs Institute and New-Castle Ottawa scale were used for case reports and cohort studies, respectively. The meta-analysis was completed using R-Studio and its associated "metafor" package.

resultsA comprehensive search in four databases yielded 70 case reports/series (

conclusionscvPRES is most often associated with higher blood pressure compared to prior studies with typical PRES. The pons is most often involved. Despite the severity of blood pressure and critical brain stem involvement, those with cvPRES have favorable functional outcomes and a lower mortality rate than typical PRES, likely attributable to reversible vasogenic edema without significant neuronal dysfunction.

Indexed as

central variantmeta-analysisposterior reversible encephalopathy syndromeposterior reversible leukoencephalopathy syndromePRESsystematic review

Identifiers

PMID40710916
PMCPMC12298113

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.