ArticleTomography (Ann Arbor, Mich.)2025
Qualitative and Quantitative Computed Tomography Analyses of Lung Adenocarcinoma for Predicting Spread Through Air Spaces.
Article in Tomography (Ann Arbor, Mich.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Machine learning-based preoperative prediction of spread through air spaces in clinical stage IA non-small cell lung cancer: a single-center study integrating clinical and CT imaging characteristics.Journal of thoracic disease · 2026Article
- Preoperative low-attenuation area on computed tomography is associated with recurrence after curative resection for non-small-cell lung cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Multidisciplinary Perspective of Spread Through Air Spaces in Lung Cancer: A Narrative Review.Cancers · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesSpread through air spaces (STAS) is defined as the spread of tumor cells into the parenchymal alveolar space beyond the margins of the main tumor, and it is associated with worse clinical outcomes in resected lung adenocarcinoma. This study aimed to evaluate the preoperative computed tomography (CT) findings of primary lung adenocarcinoma in surgically resected T1 cases and to compare CT findings with and without STAS.
methodsA total of 145 patients were included in this study. The following factors were evaluated on CT images: nodule type (pure ground-glass nodule [GGN], part-solid nodule, or solid nodule), margin (smooth or irregular), the presence of lobulation, spicula, cavity, calcification, central low attenuation, peripheral opacity (well-defined or ill-defined), air bronchogram, satellite lesions, pleural retraction, pulmonary emphysema, and interstitial pneumonia; CT values (maximum, minimum, and mean); volume (tumor and solid component); and diameter (tumor and solid component). CT criteria were compared between the presence and absence of STAS.
resultsLobulation and central low attenuation were significantly more frequent in patients with STAS (
conclusionsQuantitative and qualitative analyses are useful for differentiating between the presence and absence of STAS.
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