ArticleJournal of cardiovascular development and disease2025
Mid-Term Recovery of Right Ventricular Function and Improvement of Left Ventricular Function After Da Silva Cone Procedure for Ebstein Anomaly.
Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Anatomical severity of Ebstein's anomaly: a quantitative analysis based on cardiovascular MRI.Open heart · 2026Article
- Primary Tricuspid Regurgitation in ACHD: Diagnosis and Treatment.Methodist DeBakey cardiovascular journal · 2026Review
- Comparative study of transcatheter aortic valve implantation versus conventional surgical aortic valve replacement in the treatment of severe aortic stenosis with reverse ventricular remodeling.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe Da Silva Cone procedure for Ebstein anomaly has dramatically improved tricuspid valve competence and clinical outcomes. However, preoperative left ventricular (LV) dysfunction and immediate postoperative right ventricular (RV) systolic dysfunction are frequently observed. While excellent valve outcomes are well established, recovery of biventricular function following the Cone remains less defined. This study aimed to evaluate longitudinal changes in RV and LV function postoperatively and over a minimum of six months post-Cone operation.
methodsA single center retrospective review of 134 patients who underwent Cone repair for Ebstein's anomaly from 2016 to 2024 was performed. Echocardiograms were analyzed at three time points: preoperative (Time 1), hospital discharge (Time 2), and ≥6 months postoperative (Time 3). RV parameters included fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE), and tricuspid S'. LV parameters included left ventricular ejection fraction (LVEF), end-diastolic volume indexed to body surface area (LVEDVi), left ventricular stroke volume (LVSVi), and mitral E/E'. Subgroup analyses examined outcomes by prior Glenn, Starnes procedure, and degree of RV dilation. Paired two sample
resultsMedian age at surgery was 7.8 years (IQR: 2.3-17.7). All patients had discharge echocardiograms; 70 had follow-up studies at ≥6 months. RV function declined postoperatively with reductions in FAC (35% to 21%), TAPSE (2.0 to 0.8 cm), and S' (13 to 5 cm/s), all
conclusionsThe Da Silva Cone procedure leads to early postoperative RV dysfunction with partial recovery over the mid-term follow-up. Concurrently, LV filling and stroke volume improve, reflecting favorable interventricular interaction. These findings support echocardiographic surveillance to guide functional recovery post-Cone and inform patient counseling.
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