Evidence map›Paper›PMID 40710780›Full record

ReviewJournal of cardiovascular development and disease2025

Discordant High-Gradient Aortic Stenosis: A Systematic Review.

Nadera N Bismee, Mohammed Tiseer Abbas, Hesham Sheashaa, Fatmaelzahraa E Abdelfattah, Juan M Farina, Kamal Awad, Isabel G Scalia, Milagros Pereyra Pietri, Nima Baba Ali, Sogol Attaripour Esfahani and 5 more

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nadera N BismeeDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0009-0001-7502-0992
Mohammed Tiseer AbbasDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0009-0004-7212-435X
Hesham SheashaaDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0009-0000-4740-5388
Fatmaelzahraa E AbdelfattahDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0009-0008-0758-1086
Juan M FarinaDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0000-0002-5824-8485
Kamal AwadDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.
Isabel G ScaliaDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0000-0002-6459-9767
Milagros Pereyra PietriDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0000-0003-4695-8436
Nima Baba AliDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0009-0004-3979-0609
Sogol Attaripour EsfahaniDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.
Omar H IbrahimDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0009-0003-2530-7850
Steven J LesterDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.
Said AlsidawiDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0000-0001-8750-7880
Chadi AyoubDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.
Reza ArsanjaniDepartment of Cardiovascular Medicine, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.ORCID 0000-0001-7081-4286

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aortic stenosis (AS), the most common valvular heart disease, is traditionally graded based on several echocardiographic quantitative parameters, such as aortic valve area (AVA), mean pressure gradient (MPG), and peak jet velocity (Vmax). This systematic review evaluates the clinical significance and prognostic implications of discordant high-gradient AS (DHG-AS), a distinct hemodynamic phenotype characterized by elevated MPG despite a preserved AVA (>1.0 cm

Indexed as

aortic stenosisaortic valve calcificationaortic valve replacementdiscordant high gradient aortic stenosis

Identifiers

PMID40710780
PMCPMC12296130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.