Evidence map›Paper›PMID 40710503›Full record

ArticleMarine drugs2025

Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging.

Ana Jesus, Sara Gimondi, Sónia A Pinho, Helena Ferreira, Nuno M Neves, Andreia Palmeira, Emília Sousa, Isabel F Almeida, Maria T Cruz, Honorina Cidade

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana JesusAssociate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Sara Gimondi3B's Research Group, I3BS-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edificio 1 (Sede), Barco, 4805-694 Guimarães, Portugal.
Sónia A PinhoCNC-Center for Neuroscience and Cell Biology, Centre for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.ORCID 0000-0002-7426-5197
Helena Ferreira3B's Research Group, I3BS-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edificio 1 (Sede), Barco, 4805-694 Guimarães, Portugal.ORCID 0000-0002-3770-9393
Nuno M Neves3B's Research Group, I3BS-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edificio 1 (Sede), Barco, 4805-694 Guimarães, Portugal.ORCID 0000-0003-3041-0687
Andreia PalmeiraLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge de Viterbo Ferreira, 288, 4050-313 Porto, Portugal.ORCID 0000-0002-1391-2143
Emília SousaLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge de Viterbo Ferreira, 288, 4050-313 Porto, Portugal.ORCID 0000-0002-5397-4672
Isabel F AlmeidaAssociate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-1498-048X
Maria T CruzCNC-Center for Neuroscience and Cell Biology, Centre for Innovative Biomedicine and Biotechnology (CIBB), 3004-504 Coimbra, Portugal.ORCID 0000-0001-9846-6754
Honorina CidadeLaboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge de Viterbo Ferreira, 288, 4050-313 Porto, Portugal.ORCID 0000-0003-0715-1779

Funding

INSTRUMENTAL ANALYSISZ01CT000014 · CIT · COMPUTER RESEARCH AND TECHNOLOGY · PI WEISS, GEORGE H · 1985 to 2008
$408k
Fundação para a Ciência e Tecnologia Ana Jesus acknowledges her Ph.D. grant with doi:10.54499/UIDP/04378/2020, totally financed by FCT.Fundação para a Ciência e Tecnologia in the scope of the projects https://doi.org/10.54499/UIDP/04378/2020 and https://doi.org/10.54499/UIDP/04378/2020 of the Research Unit on Applied Molecular Biosciences - UCIBIOFundação para a Ciência e Tecnologia the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000012 (HealthyAging2020)Fundação para a Ciência e Tecnologia the project https://doi.org/10.54499/UIDP/04378/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HBFundação para a Ciência e Tecnologia the projects UIDP/04539/2020, and the projects UIDP/04539/2020 and LA/P/0058/2020 from CIBBFundação para a Ciência e Tecnologia the project "TERM RES Hub - Scientific Infrastructure for Tissue Engineering and Regenerative Medicine" (PINFRA/22190/2016, Norte-01-0145-FEDER-022190), co-funded by FCT and the CCDRN)Fundação para a Ciência e Tecnologia the Sara Gimondi Individual Scientific Employment Stimulus grant (2023.06754.CEECIND/CP2841/CT0014)Fundação para a Ciência e Tecnologia the scope of the Strategic Funding UIDB/04423/2020 (https://doi.org/10.54499/UIDB/04423/2020), UIDP/04423/2020 (https://doi.org/10.54499/UIDP/04423/2020), and LA/P/0101/2020 (https://doi.org/10.54499/LA/P/0101/2020)Intramural NIH HHS Z01 CT000014
6 · The paper itself

Abstract

Skin aging is mainly caused by external factors like sunlight, which triggers oxidative stress and chronic inflammation. Natural halogenated flavonoids have demonstrated anti-inflammatory properties. Inspired by the macroalgae-derived bromophenol

Indexed as

Anti-Inflammatory AgentsChalconesCosmeticsSeaweedSkin AgingAnimalsHumansInflammationKeratinocytesMacrophagesMiceNF-E2-Related Factor 2Nitric Oxide Synthase Type IIRAW 264.7 CellsStructure-Activity RelationshipAnti-Inflammatory AgentsChalconesCosmeticsNF-E2-Related Factor 2Nitric Oxide Synthase Type IIanti-inflammatory activitybrominated chalconesiNOSmacroalgaeNrf2skin aging

Identifiers

PMID40710503
PMCPMC12299847

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.