Evidence map›Paper›PMID 40710452›Full record

ArticleJournal of functional biomaterials2025

Morphometric, Biomechanical and Macromolecular Performances of β-TCP Macro/Micro-Porous Lattice Scaffolds Fabricated via Lithography-Based Ceramic Manufacturing for Jawbone Engineering.

Carlo Mangano, Nicole Riberti, Giulia Orilisi, Simona Tecco, Michele Furlani, Christian Giommi, Paolo Mengucci, Elisabetta Giorgini, Alessandra Giuliani

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carlo ManganoDepartment of Dental Sciences, University Vita Salute San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-4419-4674
Nicole RibertiDepartment of Clinical and Molecular Sciences, Marche Polytechnic University, 60126 Ancona, Italy.ORCID 0000-0002-4798-5236
Giulia OrilisiDepartment of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy.
Simona TeccoI.R.C.C.S. San Raffaele Hospital, University Vita Salute San Raffaele, 20132 Milan, Italy.ORCID 0000-0003-2986-1114
Michele FurlaniDepartment of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy.ORCID 0000-0002-9261-2682
Christian GiommiDepartment of Life and Environmental Science, Marche Polytechnic University, 60131 Ancona, Italy.ORCID 0000-0002-8451-2569
Paolo MengucciDepartment Science and Engineering of Materials, Environment and Urban Planning, Marche Polytechnic University, 60131 Ancona, Italy.ORCID 0000-0001-9049-8524
Elisabetta GiorginiDepartment of Life and Environmental Science, Marche Polytechnic University, 60131 Ancona, Italy.ORCID 0000-0003-0503-5870
Alessandra GiulianiDepartment of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy.ORCID 0000-0003-4177-7441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective bone tissue regeneration remains pivotal in implant dentistry, particularly for edentulous patients with compromised alveolar bone due to atrophy and sinus pneumatization. Biomaterials are essential for promoting regenerative processes by supporting cellular recruitment, vascularization, and osteogenesis. This study presents the development and characterization of a novel lithography-printed ceramic β-TCP scaffold, with a macro/micro-porous lattice, engineered to optimize osteoconduction and mechanical stability. Morphological, structural, and biomechanical assessments confirmed a reproducible microarchitecture with suitable porosity and load-bearing capacity. The scaffold was also employed for maxillary sinus augmentation, with postoperative evaluation using micro computed tomography, synchrotron imaging, histology, and Fourier Transform Infrared Imaging analysis, demonstrating active bone regeneration, scaffold resorption, and formation of mineralized tissue. Advanced imaging supported by deep learning tools revealed a well-organized osteocyte network and high-quality bone, underscoring the scaffold's biocompatibility and osteoconductive efficacy. These findings support the application of these 3D-printed β-TCP scaffolds in regenerative dental medicine, facilitating tissue regeneration in complex jawbone deficiencies.

Indexed as

bone regenerationjawbone engineeringlithography-based ceramic 3D printingmaxillary sinus augmentationmicroarchitectureosteocyte lacunae networkscaffoldβ-TCP

Identifiers

PMID40710452
PMCPMC12295332

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.