Evidence map›Paper›PMID 40710364›Full record

ArticleCells2025

Female Mice Lacking LSD1 in Myeloid Cells Are Resistant to Inflammatory Bone Loss.

Kristina Astleford-Hopper, Flavia Saavedra, Peter Bittner-Eddy, Clara Stein, Jennifer Auger, Rachel Clark, Juan E Abrahante Llorens, Bryce A Binstadt, Vivek Thumbigere-Math, Kim C Mansky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristina Astleford-HopperOral Biology Graduate Program, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA.
Flavia SaavedraOral Biology Graduate Program, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA.
Peter Bittner-EddyDivision of Biological Science, Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA.
Clara SteinCollege of Biological Science, University of Minnesota, Minneapolis, MN 55455, USA.
Jennifer AugerDivision of Pediatric Rheumatology, Allergy and Immunology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0003-2707-7561
Rachel ClarkOral Biology Graduate Program, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA.
Juan E Abrahante LlorensMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9074-4307
Bryce A BinstadtDivision of Pediatric Rheumatology, Allergy and Immunology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID 0000-0003-3127-3856
Vivek Thumbigere-MathDivision of Periodontology, Department of Advanced Oral Sciences, Therapeutics University of Maryland School of Dentistry, Baltimore, MD 21201, USA.ORCID 0000-0002-8279-3766
Kim C ManskyDivision of Orthodontics, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA.ORCID 0000-0002-2826-5030

Funding

Minnesota Craniofacial and Oral Health Research ExperienceR25DE032529 · NIDCR · UNIVERSITY OF MINNESOTA · PI Kim Carpenter Mansky · 2023 to 2026
$521k
The role of LSD1 in regulating periodontal induced bone lossR21DE034067 · NIDCR · UNIVERSITY OF MINNESOTA · PI Kim Carpenter Mansky · 2025 to 2026
$435k
NIDCR NIH HHS R21 DE034067NIDCR NIH HHS R25 DE032529NIH HHS 1R21DE034067-01
6 · The paper itself

Abstract

Osteoclasts, which are derived from myeloid precursors, are essential for physiologic bone remodeling but also mediate pathological bone loss in inflammatory diseases such as periodontitis and rheumatoid arthritis. Lysine-specific demethylase (LSD1/KDM1A) is a histone demethylase that modulates the chromatin landscape via demethylation of H3K4me1/2 and H3K9me1/2, thereby regulating the expression of genes essential for deciding cell fate. We previously demonstrated that myeloid-specific deletion of LSD1 (LSD1LysM-Cre) disrupts osteoclast differentiation, leading to enhanced BV/TV under physiological conditions. In this study, we show that LSD1LysM-Cre female mice are similarly resistant to inflammatory bone loss in both ligature-induced periodontitis and K/BxN serum-transfer arthritis models. Bulk RNA-seq of mandibular-derived preosteoclasts from LSD1LysM-Cre mice with ligature-induced periodontitis revealed the upregulation of genes involved in inflammation, lipid metabolism, and immune response. Notably, LSD1 deletion blocked osteoclastogenesis even under TGF-β and TNF co-stimulation, which is an alternative RANKL-independent differentiation pathway. Upregulation of

Indexed as

Bone ResorptionHistone DemethylasesInflammationMyeloid CellsAnimalsCell DifferentiationFemaleMiceMice, Inbred C57BLMice, KnockoutOsteoclastsOsteogenesisPeriodontitisHistone DemethylasesKDM1a protein, mouseepigeneticsinflammationosteoclastsperiodontal disease

Identifiers

PMID40710364
PMCPMC12293761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.