Evidence map›Paper›PMID 40710362›Full record

ArticleCells2025

Discovery of

Haiyang Zhao, Tianyu Huang, Dhruva D Dhavale, Jennifer Y O'Shea, Zsofia Lengyel-Zhand, Dinahlee Saturnino Guarino, Jiwei Gu, Xuyi Yue, Ying-Hwey Nai, Hao Jiang and 10 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Haiyang ZhaoDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0009-0002-3167-6479
Tianyu HuangDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-5607-4901
Dhruva D DhavaleDepartment of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
Jennifer Y O'SheaDepartment of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
Zsofia Lengyel-ZhandDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dinahlee Saturnino GuarinoDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0003-3841-1825
Jiwei GuDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-4908-7544
Xuyi YueDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-3783-6392
Ying-Hwey NaiDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0002-6634-8785
Hao JiangDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Marshall G LougeeDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Vinayak V PagarDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hee Jong KimDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Benjamin A GarciaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
E James PeterssonDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-3854-9210
Chester A MathisDepartment of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-9811-0950
Paul T KotzbauerDepartment of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
Joel S PerlmutterDepartment of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7645-2869
Zhude TuDepartment of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.

Funding

Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI JOEL Synes PERLMUTTER · 2019 to 2026
$44.1M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
DEVELOPMENT OF VESICULAR ACETYLCHOLINE TRANSPORTER IMAGING AGENTS FOR PETR21NS061025 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2009 to 2010
$628k
NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS134586NINDS NIH HHS R21 NS061025NINDS NIH HHS U19 NS110456
6 · The paper itself

Abstract

The fibrillary aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a potential target for diagnostics and therapeutics. Although substantial effort has been devoted to the development of positron emission tomography (PET) probes for detecting α-synuclein aggregates, no clinically suitable tracer has been reported. The design and synthesis of 43 new

Indexed as

alpha-SynucleinParkinson DiseasePositron-Emission TomographyProtein AggregatesQuinolinesAnimalsBrainHumansMalealpha-SynucleinProtein AggregatesQuinolinesParkinson’s diseasePET imagingradiolabelingtracer developmentα-synuclein aggregates

Identifiers

PMID40710362
PMCPMC12293736

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.