Evidence map›Paper›PMID 40710337›Full record

ReviewCells2025

The Sex Difference in the Pathophysiology of Preterm Birth.

Gain Lee, Gisela Martinez Andrade, Young Ju Kim, Dilly O C Anumba

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gain LeeGraduate Program in System Health Science and Engineering, Ewha Womans University, Seoul 03760, Republic of Korea.
Gisela Martinez AndradeDivision of Clinical Medicine, School of Medicine & Population Health, Faculty of Health, The University of Sheffield, Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK.
Young Ju KimGraduate Program in System Health Science and Engineering, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0000-0002-3153-3008
Dilly O C AnumbaDivision of Clinical Medicine, School of Medicine & Population Health, Faculty of Health, The University of Sheffield, Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK.

Funding

Ministry of Health & Welfare, Republic of Korea RS-2023-00266554National Research Foundation of Korea NRF-5199990614253
6 · The paper itself

Abstract

Preterm birth (PTB) refers to a labor before 37 gestational weeks. This is a major global contributor to neonatal morbidity and mortality. Although fetal sex is frequently treated as a confounding variable in PTB research, relatively few studies have conducted sex-stratified analyses to investigate how male and female fetuses may respond differently to various intrauterine exposures. This represents an underexplored area with important implications for understanding fetal sexual dimorphism-specific vulnerability to adverse pregnancy outcomes. Understanding the role of fetal sex differences in the pathophysiology of preterm birth (PTB) regarding processes such as inflammation, placental dysfunction, and oxidative stress is crucial. These delicate processes are tightly interrelated, but also independently contribute to pregnancy complications. Recognizing fetal sex as a biological variable for such processes is essential for improving mechanistic insight, providing refined predictive models.

Indexed as

Premature BirthSex CharacteristicsFemaleHumansInfant, NewbornMaleOxidative StressPlacentaPregnancyinflammationoxidative stressplacental dysfunctionpreterm birthsex-specific manner

Identifiers

PMID40710337
PMCPMC12293432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.