Evidence map›Paper›PMID 40710323›Full record

ArticleCells2025

Regulation of Hindbrain Vascular Development by

Xinyu Shen, Zhaozhi Wen, Shunze Deng, Yuxuan Qiu, Weijie Ma, Xinyue Dong, Jie Gong, Yu Zhang, Dong Liu, Bing Xu

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinyu ShenSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Zhaozhi WenSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Shunze DengSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Yuxuan QiuSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Weijie MaSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Xinyue DongSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Jie GongSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Yu ZhangSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Dong LiuSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.ORCID 0000-0002-2764-6544
Bing XuSchool of Life Sciences, Nantong University, 9 Seyuan Road, Nantong 226019, China.ORCID 0009-0009-3621-0994

Funding

Jiangsu Natural Science Foundation bk20230611Nantong Natural Science Foundation jc2023046NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA 82472680, 82303471
6 · The paper itself

Abstract

During aging, the brain vasculature undergoes significant deterioration characterized by increased arterial tortuosity, compromised blood-brain barrier integrity, and reduced cerebral blood flow, all of which contribute to various neurological disorders. Thus, understanding the mechanisms underlying aging-related cerebrovascular defects is critical for developing strategies to alleviate aging-associated neurological diseases. In this study, we investigated the role of aging-related genes in brain vascular development using zebrafish as an in vivo model. By thoroughly analyzing scRNA-seq datasets of mid- and old-aged brain vascular endothelial cells (human/mouse), we found

Indexed as

Neovascularization, PhysiologicRhombencephalonRibosomal ProteinsZebrafishZebrafish ProteinsAgingAnimalsEndothelial CellsGene Expression Regulation, DevelopmentalHumansRibosomal ProteinsZebrafish Proteinsagingbrain vasculaturerps20vascular permeabilityzebrafish

Identifiers

PMID40710323
PMCPMC12293849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.