Evidence map›Paper›PMID 40710313›Full record

ReviewCells2025

A Meta-Review of Spatial Transcriptomics Analysis Software.

Jessica Gillespie, Maciej Pietrzak, Min-Ae Song, Dongjun Chung

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica GillespieDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Maciej PietrzakDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-5768-7884
Min-Ae SongDivision of Environmental Health Science, College of Public Health, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-2864-0224
Dongjun ChungDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-8072-5671

Funding

TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0M
Statistical Power Analysis Framework for Multi-Sample and Cross-Platform Spatial Omics ExperimentsR01GM152585 · NIGMS · OHIO STATE UNIVERSITY · PI Dongjun Chung, Qin Ma · 2024 to 2026
$1.2M
Statistical Power Calculation Framework for Spatially Resolved Transcriptomics ExperimentsR21HG012482 · NHGRI · OHIO STATE UNIVERSITY · PI CHUNG, DONGJUN, MA, QIN · 2022 to 2023
$421k
NHGRI NIH HHS R21 HG012482NIA NIH HHS U54 AG075931NIGMS NIH HHS R01 GM152585NIH HHS 1R01GM152585-01NIH HHS 1R21HG012482-01NIH HHS 1U54AG075931-04Pelotonia Institute for Immuno-Oncology (PIIO) N/A
6 · The paper itself

Abstract

Spatial transcriptomics combines gene expression data with spatial coordinates to allow for the discovery of detailed RNA localization, study development, investigating the tumor microenvironment, and creating a tissue atlas. A large range of spatial transcriptomics software is available, with little information on which may be better suited for particular datasets or computing environments. A review was conducted to detail the useful metrics when choosing appropriate software for spatial transcriptomics analysis. Specifically, the results from benchmarking studies that compared software across four key areas of spatial transcriptomics analysis (tissue architecture identification, spatially variable gene discovery, cell-cell communication analysis, and deconvolution) were assimilated into a single review that can serve as guidance when choosing potential spatial transcriptomics analysis software.

Indexed as

Gene Expression ProfilingSoftwareTranscriptomeComputational BiologyHumansbenchmarkingcell–cell communicationdeconvolutionspatially variable genespatial transcriptomicstissue architecture identification

Identifiers

PMID40710313
PMCPMC12293887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.