Evidence map›Paper›PMID 40710311›Full record

ArticleCells2025

Hypergravity and ERK Inhibition Combined Synergistically Reduce Pathological Tau Phosphorylation in a Neurodegenerative Cell Model.

Valerio Mignucci, Ivana Barravecchia, Davide De Luca, Giacomo Siano, Cristina Di Primio, Jack J W A van Loon, Debora Angeloni

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Valerio MignucciGraduate School in Translational Medicine, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124 Pisa, Italy.
Ivana BarravecchiaThe Institute of Biorobotics, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124 Pisa, Italy.
Davide De LucaGraduate School in Translational Medicine, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124 Pisa, Italy.ORCID 0009-0008-8701-5147
Giacomo SianoInstitute of Neuroscience, National Research Council of Italy, Via G. Moruzzi, 1, 56124 Pisa, Italy.ORCID 0000-0003-4320-5631
Cristina Di PrimioInstitute of Neuroscience, National Research Council of Italy, Via G. Moruzzi, 1, 56124 Pisa, Italy.
Jack J W A van LoonDepartment of Oral and Maxillofacial Surgery/Oral Pathology, Amsterdam UMC Location VUmc and Academic Center for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0001-9051-6016
Debora AngeloniGraduate School in Translational Medicine, Scuola Superiore Sant'Anna, Via G. Moruzzi, 1, 56124 Pisa, Italy.

Funding

European Space Agency SYT2020
6 · The paper itself

Abstract

This study evaluates the effects of hypergravity (HG) on a neurodegenerative model in vitro, looking at how HG influences Tau protein aggregation in Mouse Hippocampal Neuronal Cells (HT22) induced by neurofibrillary tangle seeds. Overall, 50×

Indexed as

Extracellular Signal-Regulated MAP KinasesHypergravityNeurodegenerative DiseasesProtein Kinase Inhibitorstau ProteinsAnimalsCell LineHippocampusMiceModels, BiologicalNeuronsPhosphorylationExtracellular Signal-Regulated MAP KinasesProtein Kinase Inhibitorstau ProteinsEuropean Space Agency (ESA)hypergravitylarge diameter centrifuge (LDC)neurodegenerationPD-0325901tauopathies

Identifiers

PMID40710311
PMCPMC12293720

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.