Evidence map›Paper›PMID 40710110›Full record

SynthesisBiosensors2025

Optical and Electrochemical Biosensors for Detection of Pathogens Using Metal Nanoclusters: A Systematic Review.

Mahsa Shahrashoob, Mahdiyar Dehshiri, Vahid Yousefi, Mahdi Moassesfar, Hamidreza Saberi, Fatemeh Molaabasi, Yasser Zare, Kyong Yop Rhee

Abstract readSystematic Review
In one paragraph

Synthesis in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahsa ShahrashoobDepartment of Biochemistry and Biophysics, TeMS.C., Islamic Azad University, Tehran 1811694784, Iran.
Mahdiyar DehshiriMedical Nanotechnology Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.ORCID 0009-0003-3643-3692
Vahid YousefiMedical Nanotechnology Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.
Mahdi MoassesfarDepartment of Biochemistry and Biophysics, TeMS.C., Islamic Azad University, Tehran 1811694784, Iran.ORCID 0009-0009-3313-4930
Hamidreza SaberiMedical Nanotechnology Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.
Fatemeh MolaabasiMedical Nanotechnology Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.
Yasser ZareBiomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.ORCID 0000-0002-1293-8878
Kyong Yop RheeDepartment of Mechanical Engineering (BK21 Four), College of Engineering, Kyung Hee University, Yongin 17104, Republic of Korea.ORCID 0000-0001-7269-9728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid and accurate detection of pathogenic bacteria and viruses is critical for infectious disease control and public health protection. While conventional methods (e.g., culture, microscopy, serology, and PCR) are widely used, they are often limited by lengthy processing times, high costs, and specialized equipment requirements. In recent years, metal nanocluster (MNC)-based biosensors have emerged as powerful diagnostic platforms due to their unique optical, catalytic, and electrochemical properties. This systematic review comprehensively surveys advancements in MNC-based biosensors for bacterial and viral pathogen detection, focusing on optical (colorimetric and fluorescence) and electrochemical platforms. Three key aspects are emphasized: (1) detection mechanisms, (2) nanocluster types and properties, and (3) applications in clinical diagnostics, environmental monitoring, and food safety. The literature demonstrates that MNC-based biosensors provide high sensitivity, specificity, portability, and cost-efficiency. Moreover, the integration of nanotechnology with biosensing platforms enables real-time and point-of-care diagnostics. This review also discusses the limitations and future directions of the technology, emphasizing the need for enhanced stability, multiplex detection capability, and clinical validation. The findings offer valuable insights for developing next-generation biosensors with improved functionality and broader applicability in microbial diagnostics.

Indexed as

BacteriaBiosensing TechniquesElectrochemical TechniquesMetal NanoparticlesHumansVirusesbacterial detectionmetal nanocluster-based biosensorsmicrobial infectionsnanobiosensorsvirus detection

Identifiers

PMID40710110
PMCPMC12293134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.