Evidence map›Paper›PMID 40710103›Full record

ArticleBiosensors2025

Sensitivity and Cross-Reactivity Analysis of Serotype-Specific Anti-NS1 Serological Assays for Dengue Virus Using Optical Modulation Biosensing.

Sophie Terenteva, Linoy Golani-Zaidie, Shira Avivi, Yaniv Lustig, Victoria Indenbaum, Ravit Koren, Tran Mai Hoa, Tong Thi Kim Tuyen, Ma Thi Huyen, Nguyen Minh Hoan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sophie TerentevaFaculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Max and Anna Webb Street, Ramat Gan 5290002, Israel.
Linoy Golani-ZaidieFaculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Max and Anna Webb Street, Ramat Gan 5290002, Israel.ORCID 0009-0005-5510-3503
Shira AviviFaculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Max and Anna Webb Street, Ramat Gan 5290002, Israel.
Yaniv LustigCentral Virology Laboratory, Israel Ministry of Health, Chaim Sheba Medical Centre, Tel-HaShomer, Ramat Gan 5262000, Israel.
Victoria IndenbaumCentral Virology Laboratory, Israel Ministry of Health, Chaim Sheba Medical Centre, Tel-HaShomer, Ramat Gan 5262000, Israel.ORCID 0000-0002-7675-0591
Ravit KorenCentral Virology Laboratory, Israel Ministry of Health, Chaim Sheba Medical Centre, Tel-HaShomer, Ramat Gan 5262000, Israel.
Tran Mai HoaDepartment of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi 115600, Vietnam.
Tong Thi Kim TuyenDepartment of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi 115600, Vietnam.
Ma Thi HuyenDepartment of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi 115600, Vietnam.
Nguyen Minh HoanDepartment of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi 115600, Vietnam.
Le Thi HoiDepartment of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi 115600, Vietnam.
Nguyen Vu TrungPasteur Institute of Ho Chi Minh City, 167 Pasteur Street, District 3, Ho Chi Minh City 722700, Vietnam.ORCID 0000-0001-6491-2808
Eli SchwartzThe Center for Geographic Medicine, Chaim Sheba Medical Centre, Tel HaShomer, Ramat Gan 5262000, Israel.ORCID 0000-0002-4673-9084
Amos DanielliFaculty of Engineering, The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Max and Anna Webb Street, Ramat Gan 5290002, Israel.ORCID 0000-0002-4091-0493

Funding

Israel Ministry of Science and Technology 101790Israel Science Foundation 2481/19Ministry of Science and Technology, Vietnam NĐT/IL/21/10Wellcome Trust 103343
6 · The paper itself

Abstract

Dengue virus (DENV) poses a major global health concern, with over 6.5 million cases and 7300 deaths reported in 2023. Accurate serological assays are essential for tracking infection history, evaluating disease severity, and guiding vaccination strategies. However, existing assays are limited in their specificity, sensitivity, and cross-reactivity. Using optical modulation biosensing (OMB) technology and non-structural protein 1 (NS1) antigens from DENV-1-3, we developed highly sensitive and quantitative serotype-specific anti-DENV NS1 IgG serological assays. The OMB-based assays offered a wide dynamic range (~4-log), low detection limits (~400 ng/L), fast turnaround (1.5 h), and a simplified workflow. Using samples from endemic (Vietnam) and non-endemic (Israel) regions, we assessed intra-DENV and inter-

Indexed as

Biosensing TechniquesDengueDengue VirusViral Nonstructural ProteinsAntibodies, ViralCross ReactionsHumansSensitivity and SpecificitySerogroupAntibodies, ViralViral Nonstructural Proteinscross-reactivitydengue virusJapanese encephalitis virusnon-structural protein 1optical detectionserologyWest Nile viruszika virus

Identifiers

PMID40710103
PMCPMC12293919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.