ArticleBiosensors2025
Composite Metal Oxide Nanopowder-Based Fiber-Optic Fabry-Perot Interferometer for Protein Biomarker Detection.
Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
In this paper, we present the development of a new semi-distributed interferometer (SDI) biosensor with a Zn, Cu, and Co metal oxide nanopowder coating for the detection of a kidney disease biomarker as a model system. The combination of nanopowder coating with the SDI platform opens up unique opportunities for improving measurement reproducibility while maintaining high sensitivity. The fabrication of sensors is simple, which involves one splice and subsequent cutting at the end of an optical fiber. To ensure specific detection of the biomarker, a monoclonal antibody was immobilized on the surface of the probe. The biosensor has demonstrated an impressive ability to detect biomarkers in a wide range of concentrations, from 1 aM to 100 nM. The theoretical limit of detection was 126 fM, and the attomolar detection level was experimentally achieved. The sensors have achieved a maximum sensitivity of 190 dB/RIU and operate with improved stability and reduced dispersion. Quantitative analysis revealed that the sensor's response gradually increases with increasing concentration. The signal varies from 0.05 dB at 1 aM to 0.81 dB at 100 nM, and the linear correlation coefficient was R
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