Evidence map›Paper›PMID 40710093›Full record

ReviewBiosensors2025

Electrochemical Impedance Spectroscopy-Based Biosensors for Label-Free Detection of Pathogens.

Huaiwei Zhang, Zhuang Sun, Kaiqiang Sun, Quanwang Liu, Wubo Chu, Li Fu, Dan Dai, Zhiqiang Liang, Cheng-Te Lin

Abstract readReview
In one paragraph

Review in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Acoustofluidic Biosensors.Micromachines · 2026
    Review
  7. Review
  8. Review
  9. Carbohydrate-based biosensors for enhanced pathogen detection.Analytical and bioanalytical chemistry · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Nanozymes Integrated Biochips Toward Smart Detection System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  16. Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huaiwei ZhangCollege of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
Zhuang SunQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NlMTE), Chinese Academy of Sciences, Ningbo 315201, China.
Kaiqiang SunQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NlMTE), Chinese Academy of Sciences, Ningbo 315201, China.
Quanwang LiuQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NlMTE), Chinese Academy of Sciences, Ningbo 315201, China.
Wubo ChuQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NlMTE), Chinese Academy of Sciences, Ningbo 315201, China.
Li FuCollege of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.ORCID 0000-0002-5957-7790
Dan DaiQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NlMTE), Chinese Academy of Sciences, Ningbo 315201, China.
Zhiqiang LiangFaculty of Sports Science, Ningbo University, Ningbo 315211, China.
Cheng-Te LinState Key Laboratory of Advanced Marine Materials, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, China.ORCID 0000-0002-7090-9610

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The escalating threat of infectious diseases necessitates the development of diagnostic technologies that are not only rapid and sensitive but also deployable at the point of care. Electrochemical impedance spectroscopy (EIS) has emerged as a leading technique for the label-free detection of pathogens, offering a unique combination of sensitivity, non-invasiveness, and adaptability. This review provides a comprehensive overview of the design and application of EIS-based biosensors tailored for pathogen detection, focusing on critical components such as biorecognition elements, electrode materials, nanomaterial integration, and surface immobilization strategies. Special emphasis is placed on the mechanisms of signal generation under Faradaic and non-Faradaic modes and how these underpin performance characteristics such as the limit of detection, specificity, and response time. The application spectrum spans bacterial, viral, fungal, and parasitic pathogens, with case studies highlighting detection in complex matrices such as blood, saliva, food, and environmental water. Furthermore, integration with microfluidics and point-of-care systems is explored as a pathway toward real-world deployment. Emerging strategies for multiplexed detection and the utilization of novel nanomaterials underscore the dynamic evolution of the field. Key challenges-including non-specific binding, matrix effects, the inherently low ΔR

Indexed as

Biosensing TechniquesDielectric SpectroscopyBacteriaHumansVirusesbiorecognition strategiesmicrofluidic integrationnanomaterial enhancementnon-faradaic detectionpoint-of-care diagnostics

Identifiers

PMID40710093
PMCPMC12293632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.