ArticleMicrobiology spectrum2025
The negligible mutagenic effects of norfloxacin on the genome of the fission yeast
Tongtong Lin, Xiaolin Wu, Yelin Lan, Yongchun Huang, Ziguang Deng, Yu Zhang, Michael Lynch, Hongan Long, Jiao Pan
Abstract read
In one paragraphArticle in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Tongtong LinKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.ORCID 0000-0002-3515-2018 Xiaolin WuKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.
Yelin LanKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.
Yongchun HuangKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.
Ziguang DengKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.
Yu ZhangKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.ORCID 0000-0001-9179-0922 Michael LynchBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, Arizona, USA.
Hongan LongKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.
Jiao PanKey Laboratory of Evolution and Marine Biodiversity (Ministry of Education), Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, Shandong Province, China.ORCID 0000-0003-3849-2891 Funding
Causes and Population-genetic Consequences of Molecular VariationR35GM122566 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael R LYNCH · 2017 to 2026
$7.7MFundamental Research Funds for the Central Universities 202413027National Institute of Health MIRA grant 2R35GM122566National Natural Science Foundation of China 32270435, 32471688NIGMS NIH HHS R35 GM122566Postdoctoral Fellowship Program of CPSf GZC20232504Shandong Provincial Natural Science Foundation ZR2023QC191Taishan Scholars Program of Shandong Province tstp20240813
6 · The paper itselfAbstract
Antibiotic therapy is commonly used in various medical scenarios, and some antibiotics will stay in the blood serum for days. Previous studies have demonstrated that the fluoroquinolone antibiotic norfloxacin exerts mutagenic effects on the whole genomes of target bacteria. However, whether and to what degree these effects compromise non-target eukaryotic genomes remains unclear. Here, we explored this using mutation accumulation experiments with the fission yeast
Indexed as
Anti-Bacterial AgentsGenome, FungalMutagensNorfloxacinSchizosaccharomycesDNA RepairHumansMutationMutation RateAnti-Bacterial AgentsMutagensNorfloxacinantibiotic-induced mutagenesisevolutionmutation accumulationmutations
Identifiers
PMID40709928
PMCPMC12403669
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