Evidence map›Paper›PMID 40709894›Full record

ArticleJournal of clinical pharmacology2025

Four Pharmacogenomic Variants Strongly Linked to Corticosteroid-Induced Avascular Necrosis in Children with Cancer.

Miguel Cordova-Delgado, Erika N Scott, Shahrad R Rassekh, Catrina M Loucks, Wan-Chun Chang, Edward J Raack, Jessica N Trueman, Colin J D Ross, Bruce C Carleton, Canadian Pharmacogenomics Network for Drug Safety Consortium

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miguel Cordova-DelgadoDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-3132-226X
Erika N ScottDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Shahrad R RassekhBC Children's Hospital Research Institute, Vancouver, Canada.
Catrina M LoucksDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0003-1167-3721
Wan-Chun ChangDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Edward J RaackBC Children's Hospital Research Institute, Vancouver, Canada.ORCID https://orcid.org/0000-0001-9730-9415
Jessica N TruemanDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Colin J D RossBC Children's Hospital Research Institute, Vancouver, Canada.
Bruce C CarletonDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Canadian Pharmacogenomics Network for Drug Safety Consortium

Funding

BC Children's Hospital Research Institute (BCCHR)BCCHR Bertram Hoffmeister PostdoctoralBCCHR Investigator Establishment AwardCIHR #GP1-155872CIHR DSECT FRN 164641Genome British Columbia 272PGXGenome CanadaGenomic and Outcomes Databank for Pharmacogenomic and Implementation Studies (GO-PGx)Health CanadaInternational Association for the Study of Pain John J. Bonica TraineeLarge-Scale Applied Research Project CompetitioProvincial Health Services AuthorityUniversity of British Columbia Four-Year Doctoral
6 · The paper itself

Abstract

Corticosteroids are effective anti-cancer agents for treating hematologic malignancies in children. However, avascular necrosis (AVN) is a common and debilitating adverse effect, leading to bone death and impacting long-term quality of life. This study aimed to uncover the genetic factors contributing to corticosteroid-induced AVN in a well-characterized cohort of pediatric cancer patients. We conducted a genome-wide association study (GWAS) on 972 patients, including 108 with AVN grade ≥2 and 864 dose-matched controls. The GWAS of 6.4 million genetic markers identified four significant AVN-associated loci (P < 5 × 10

Indexed as

Adrenal Cortex HormonesNeoplasmsOsteonecrosisPharmacogenomic VariantsAdolescentChildChild, PreschoolFemaleGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideAdrenal Cortex Hormonesadverse drug reactioncorticosteroidgenome‐wide association studypediatric oncologyWnt signaling

Identifiers

PMID40709894
PMCPMC12649305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.