Evidence map›Paper›PMID 40709841›Full record

ArticleJournal of clinical laboratory analysis2025

Serum Circ-DLGAP4 and miR-9 as Potential Biomarkers in Pancreatic Cancer.

Marwa A Ali, Olfat G Shaker, Eman M Ezzat, Mohamed Saad Zaghloul Ahmed, Shimaa Mohammed Elasmer, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Zaidan, Raghda Yahia Abu El-Ela, Marwa N AbdelHafez, Eman Fares and 4 more

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Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

14 authors.

Marwa A AliDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.ORCID https://orcid.org/0000-0002-4007-7868
Olfat G ShakerDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-3031-3599
Eman M EzzatDepartment of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Mohamed Saad Zaghloul AhmedDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Shimaa Mohammed ElasmerDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Marwa Mamdouh Ahmed AbdelhafeezDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Mohamed ZaidanDepartment of General Surgery, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Raghda Yahia Abu El-ElaDepartment of Clinical Oncology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Marwa N AbdelHafezDepartment of Medical Oncology, National Cancer Institute, Cairo University, Al Giza, Egypt.
Eman FaresDepartment of Tropical Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Ahmad A Al AbdulqaderDepartment of Surgery, College of Medicine, King Faisal University, Al Hofuf, Kingdom of Saudi Arabia.
Aeshah A AwajiDepartment of Biology, Faculty of Science, University College of Taymaa, University of Tabuk, Tabuk, Saudi Arabia.
Mariam K AlamoudiDepartment of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Omayma O AbdelaleemDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.ORCID https://orcid.org/0000-0003-2881-6776

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic cancer remains one of the malignancies characterized by the most insidious onset and dire prognosis. Preliminary diagnostic biomarkers are essential for timely identification and improved prognosis. CircularRNA-DLGAP4 (Circ-DLGAP4) and microRNA-9 (miR-9) are intriguing, easily accessible genetic indicators for numerous diseases.

aimTo quantify serum expression levels of Circ-DLGAP4 and miR-9 in pancreatic cancer patients and juxtapose these values with those of control persons to assess their potential as diagnostic biomarkers. It also aims to correlate their expression levels with the clinicopathological features of the disease.

methodQuantitative analysis of serum samples collected from 40 pancreatic cancer patients and 40 control subjects with RT-PCR.

resultsThere were statistically significant elevations in blood levels of Circ-DLGAP4 and miR-9 in pancreatic cancer patients compared to healthy persons, with median (range) values of 8.2 (0.39-17.32), p-value < 0.001, and 9.5 (4.06-14.7), respectively. The blood level of Circ-DLGAP4 exhibited a significant positive correlation with the serum concentration of miR-9 (r = 0.89, p = 0.001).

conclusionsCirc-DLGAP4 and miR-9 serve as diagnostic biomarkers for pancreatic cancer.

Indexed as

Biomarkers, TumorMicroRNAsPancreatic NeoplasmsRNA, CircularAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedBiomarkers, TumorMicroRNAsMIRN92 microRNA, humanRNA, CircularCirc‐DLGAP4miR‐9pancreatic carcinoma

Identifiers

PMID40709841
PMCPMC12378365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.