Evidence map›Paper›PMID 40709711›Full record

ArticleJournal of attention disorders2025

ADHD in Youth With Major Depressive Disorder in the Texas Youth Depression and Suicide Research Network (TX-YDSRN): Clinical Correlates and Moderators.

Blake M Upshaw, Samuel D Spencer, Caitlin M Pinciotti, Vadym Zhyrov, Abu Minhajuddin, Ace A Castillo, Allyssa Abacan, Holli Slater, Rachel A Walker, Joseph C Blader and 10 more

Abstract read
In one paragraph

Article in Journal of attention disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Adolescent depressive disorder: prevalence, risk factors, current status of diagnosis and treatment, and challenges].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Blake M UpshawMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-6609-233X
Samuel D SpencerMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-2840-4037
Caitlin M PinciottiMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-6481-3348
Vadym ZhyrovCenter for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute, and Department of Psychiatry University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1414-3120
Abu MinhajuddinCenter for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute, and Department of Psychiatry University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ace A CastilloMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0008-3012-8757
Allyssa AbacanDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-2419-5503
Holli SlaterCenter for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute, and Department of Psychiatry University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rachel A WalkerCenter for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute, and Department of Psychiatry University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-3222-2305
Joseph C BladerDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Sarah L MartinDepartment of Psychiatry, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.ORCID 0000-0003-3139-2783
Jeffrey D ShahidullahDepartment of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, Austin, TX, USA.ORCID 0000-0003-2123-0609
Jair C SoaresUniversity of Texas Health Science Center Houston, Houston, TX, USA.
Robert Andrew HarperDepartment of Psychiatry and Behavioral Sciences and College of Medicine, Texas A&M University, Bryan, TX, USA.
Madelyn GuerraJPS Health Network, Fort Worth, TX, USA.
Lynnel C GoodmanCenter for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute, and Department of Psychiatry University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wayne K GoodmanMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Sarah M WakefieldDepartment of Psychaitry and School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Madhukar H TrivediCenter for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute, and Department of Psychiatry University of Texas Southwestern Medical Center, Dallas, TX, USA.
Eric A StorchMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-7631-3703

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
NICHD NIH HHS P50 HD103555
6 · The paper itself

Abstract

objectiveDepression is a major public health concern with a 19% lifetime prevalence in youth, often precipitating other concerns, including suicidal behavior, poor school performance, and worsened peer relationships. ADHD is also common among youth and frequently presents alongside major depressive disorder (MDD), with this comorbidity associated with increased impairment. More research is needed to elucidate the clinical characteristics of this comorbidity (MDD + ADHD), especially as it relates to youth with MDD and no ADHD (MDD - ADHD). The present study examined the clinical correlates of MDD + ADHD in youth and the presence of an ADHD diagnosis as a moderator of the relationship between depressive symptoms and suicidality, peer relationships, and school functioning, respectively.

methodsOur sample included 797 youth with MDD ages 8 to 20 years (

resultsYouth with MDD + ADHD experienced more severe depressive symptoms, higher levels of suicidality, impulsivity, and irritability, and worse academic performance compared to those with MDD - ADHD. ADHD diagnosis did not moderate the relationships between depression severity and suicidality, peer relationships, or school functioning, respectively, suggesting that having an ADHD diagnosis may not affect these outcomes in depressed youth in this way.

conclusionFindings shed light on the impact of ADHD in depressed youth, which may allow for earlier and more tailored intervention efforts aimed at identifying and targeting depression, suicidality, peer relationships, and school functioning.

Indexed as

Attention Deficit Disorder with HyperactivityMajor Depressive DisorderSuicideAcademic PerformanceAdolescentChildComorbidityFemaleHumansImpulsive BehaviorMalePeer GroupSuicidal IdeationTexasYoung AdultADHDdepressionpeer functioningschool functioningsuicidal ideation

Identifiers

PMID40709711
PMCPMC12453632

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.