Evidence map›Paper›PMID 40709591›Full record

ArticleCancer medicine2025

A Data-Driven Epigenetic Characterization of Morning Fatigue Severity in Oncology Patients Receiving Chemotherapy: Associations With Epigenetic Age Acceleration, Blood Cell Types, and Expression-Associated Methylation.

Caroline Le, Maureen Lewis, Carolyn S Harris, Liam Berger, Esther Chavez-Iglesias, Lisa Morse, Anatol Sucher, Ritu Roy, Adam Olshen, Marilyn J Hammer and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Caroline LeDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Maureen LewisDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Carolyn S HarrisDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7080-4990
Liam BergerDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Esther Chavez-IglesiasDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Lisa MorseDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Anatol SucherDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Ritu RoyUniversity of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA.
Adam OlshenUniversity of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA.
Marilyn J HammerDivision of Population Sciences, Dana-Farber Cancer Institute, Nursing and Patient Care Services/Medical Oncology, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9561-6144
Steve PaulDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Margaret WallhagenDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.
Raymond ChanCollege of Nursing and Health Sciences, Caring Future Institutes, Flinders University, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0003-0248-7046
Michael SayerUniversity of California Irvine School of Pharmacy, Irvine, California, USA.ORCID https://orcid.org/0009-0001-5745-3110
Sue YomDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-0779-7476
Nam-Woo ChoDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California, USA.
Alexandre ChanUniversity of California Irvine School of Pharmacy, Irvine, California, USA.ORCID https://orcid.org/0000-0003-4391-4219
Jon LevineSchool of Dentistry, University of California San Francisco, San Francisco, California, USA.
Anand DhruvaUniversity of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA.
Christine MiaskowskiDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-5170-2027
Yvette P ConleyUniversity of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania, USA.
Kord M KoberDepartment of Physiological Nursing, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-9732-3321

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics ApproachR37CA233774 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOBER, KORD MICHAEL · 2019 to 2025
$4.8M
NCI NIH HHS CA082103NCI NIH HHS CA134900NCI NIH HHS CA233774NCI NIH HHS P30 CA082103NCI NIH HHS R01 CA134900NCI NIH HHS R37 CA233774
6 · The paper itself

Abstract

backgroundModerate-to-severe fatigue commonly occurs in patients with cancer. Given the numerous roles that epigenetic processes may play in the development and severity of fatigue, the purposes of this study were to (1) use a data-driven discovery approach to evaluate for mechanisms underlying morning fatigue in a group of oncology patients receiving chemotherapy and (2) identify common biological mechanisms associated with morning fatigue severity across these independent epigenetic evaluations.

methodsPatients completed questionnaires during the week prior to their chemotherapy treatment. Severity of morning fatigue was evaluated using the Lee Fatigue Scale. Associations between morning fatigue severity and epigenetic aging acceleration (EAA), immune cell type compositions, and differential methylation of expression-associated loci (eCpGs) in distal regions (i.e., upstream of a gene on the same chromosome) were evaluated. These results were then evaluated for common biological mechanisms.

resultsHigh morning fatigue was associated with older epigenetic age, positive EAA, and higher levels of EAA. Patients of the "Fast ager" type were more likely to have high morning fatigue. Higher morning fatigue was associated with lower (CD4 memory, CD8 memory, and NK) and higher (neutrophil and T regulatory) estimated proportions of cell types. Morning fatigue severity was associated with one differentially methylated distal region containing five eCpGs mapping to three genes (i.e., CILP, ONECUT1, SLCO3A1). Preliminary support was found for the role of Inflammaging as a common biological mechanism for morning fatigue.

conclusionsThis study provides an epigenetic characterization of morning fatigue in patients receiving chemotherapy. The findings suggest that biological aging, gene regulatory, and inflammatory processes may contribute to morning fatigue and provide future targets for therapeutic interventions.

Indexed as

AgingDNA MethylationEpigenesis, GeneticFatigueNeoplasmsAdultAgedFemaleHumansMaleMiddle AgedSeverity of Illness IndexSurveys and Questionnaires

Identifiers

PMID40709591
PMCPMC12290682

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.