Evidence map›Paper›PMID 40709571›Full record

ArticleGenome biology and evolution2025

Climate Adaptation and Genetic Differentiation in the Mosquito Species Culex tarsalis.

Yunfei Liao, Touhid Islam, Rooksana Noorai, Jared Streich, Christopher Saski, Lee W Cohnstaedt, Elizabeth A Cooper

Abstract read
In one paragraph

Article in Genome biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunfei LiaoDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.ORCID 0000-0002-1863-551X
Touhid IslamDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.ORCID 0009-0006-1181-6488
Rooksana NooraiClemson University Genomics and Bioinformatics Facility, Clemson, SC, USA.
Jared StreichBiological and Environmental Systems Science Directorate, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Christopher SaskiClemson University Genomics and Bioinformatics Facility, Clemson, SC, USA.
Lee W CohnstaedtForeign Arthropod-Borne Animal Diseases Research Unit, United States Department of Agriculture, Manhattan, KS, USA.
Elizabeth A CooperDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.ORCID 0000-0002-2688-7418

Funding

United States Department of Agriculture NACA 58-3022-1-002
6 · The paper itself

Abstract

The increasing prevalence of vector-borne diseases around the world highlights the pressing need for an in-depth exploration of the genetic and environmental factors that shape the adaptability and widespread distribution of mosquito populations. This research focuses on Culex tarsalis, a principal vector for various viral diseases including West Nile Virus. Through the development of a new reference genome and the examination of Restriction-Site Associated DNA sequencing (RAD-seq) data from over 300 individuals and 28 locations, we demonstrate that variables such as temperature, evaporation rates, and the density of vegetation significantly impact the genetic makeup of Cx. tarsalis populations. Among the alleles most strongly associated with environmental factors is a nonsynonymous mutation in a key gene related to circadian rhythms. These results offer new insights into the mechanisms of spread and adaptation in a key North American vector species, which is poised to become a growing health threat to both humans and animals in the face of ongoing climate change.

Indexed as

Adaptation, PhysiologicalCulexMosquito VectorsAnimalsClimate ChangeGenetic VariationGenome, InsectCulex tarsalislandscape genomicslocal adaptationmosquitoespopulation genetics

Identifiers

PMID40709571
PMCPMC12319148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.