ArticleAnnals of neurology2025
Subthalamic Electrophysiological Mapping of Gait Initiation Dynamics and Freezing in Parkinson's Disease.
Article in Annals of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Real-Time Kinematic Adaptive Deep Brain Stimulation Safely Reduces Gait Impairment and Freezing of Gait in Parkinson's Disease.medRxiv : the preprint server for health sciences · 2026Article
- At-home movement state classification using totally implantable cortical-basal ganglia neural interface.Science advances · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveThe objective of this study was to investigate the relationships among subthalamic nucleus (STN) activity, gait initiation (GI), and freezing of gait (FOG) in patients with Parkinson's disease (PD).
methodsWe recorded GI and STN local field potentials (LFPs) via externalized cables in 38 patients with PD (35 reporting FOG in daily life), both OFF- and ON-dopamine (DOPA). GI was also recorded in 24 age-matched controls. GI scores related to pace, rhythm, and balance were derived from kinetics, and FOG was identified using kinematics. We compared GI performance related to FOG and DOPA, and GI-LFP relationships between posterior-sensorimotor versus central-associative STN regions.
resultsDOPA
interpretationOur results reveal 3 distinct GI patterns in patients with PD associated with absence, predisposition to, or imminent occurrence of FOG, with STN neuronal modulations differing dynamically between the posterior and central subregions. These markers could support developing adaptive DBS strategies tailored for episodic gait impairments. ANN NEUROL 2025;98:977-990.
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