Evidence map›Paper›PMID 40709507›Full record

ArticleObesity (Silver Spring, Md.)2025

Placental Gene Expression Associated With Early Childhood Growth Trajectories and Obesity Risk.

Hyo Young Choi, Luhang Han, Alison G Paquette, James MacDonald, Theo Bammler, Christine Loftus, Daniel A Enquobahrie, Kaja Z LeWinn, Nicole R Bush, Catherine J Karr and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hyo Young ChoiDepartment of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-7627-8493
Luhang HanDepartment of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Alison G PaquetteCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, Washington, USA.
James MacDonaldDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Theo BammlerDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Christine LoftusDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Daniel A EnquobahrieDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California, USA.
Catherine J KarrDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Sheela SathyanarayanaDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Qi ZhaoDepartment of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-5079-1803

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Joel Daniel Kaufman · 1995 to 2026
$42.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Trans-omics Integration of Multi-omics Studies for OsteoporosisU19AG055373 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI HUI SHEN · 2017 to 2026
$24.3M
ECHO Yakima ValleyUH3OD035528 · OD · UNIVERSITY OF WASHINGTON · PI CATHERINE J KARR, Christine T Loftus · 2025 to 2026
$4.2M
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease OutcomesR01HL109977 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE · 2011 to 2015
$3.4M
Intensive Lifestyle Intervention, Metabolomics, and Risk of Frailty Fracture in Overweight or Obese Patients with Type 2 DiabetesR01AG068232 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, KAREN C, ZHAO, QI · 2021 to 2025
$3.1M
Prenatal Longitudinal Metabolomics Profiling for Early Childhood Growth Trajectories and Obesity Risk in a US Biracial Birth CohortR01DK134937 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Qi Zhao · 2023 to 2026
$3.0M
Identification of Metabolomic Profiles for Sarcopenia Traits in Older Whites and BlacksR01AG061917 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SHEN, HUI, ZHAO, QI · 2019 to 2023
$3.0M
Retaining the diverse CANDLE cohort to advance ECHO Cohort solution-oriented research and identify early-life modifiable risk factors for obesity and mental health problems in childrenUG3OD035519 · OD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BUSH, NICOLE RENEE, LEWINN, KAJA ZABRINA · 2023 to 2024
$2.9M
ECHO in Agricultural Washington and Rural Environments (ECHO AWARE)UG3OD035528 · OD · UNIVERSITY OF WASHINGTON · PI KARR, CATHERINE J · 2023 to 2024
$2.4M
NHLBI NIH HHS R01 HL109977NIA NIH HHS R01 AG061917NIA NIH HHS R01 AG068232NIA NIH HHS U19 AG055373NIDDK NIH HHS R01 DK134937NIEHS NIH HHS 2P30ES007033NIEHS NIH HHS P30 ES007033NIH HHS R01AG061917NIH HHS R01AG068232NIH HHS R01DK134937NIH HHS R01HL109977NIH HHS U19AG055373NIH HHS UG3 OD035519NIH HHS UG3OD035519NIH HHS UG3 OD035528NIH HHS UH3 OD023271NIH HHS UH3OD023271NIH HHS UH3 OD035528University of Tennessee Health Science CenterUrban Child Institute
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the association of placental gene expression with early childhood growth trajectories and obesity risk.

methodsWe analyzed 794 children from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. Placental samples collected at delivery underwent RNA sequencing to obtain transcriptome data. BMI trajectories from birth to 4 years (rising-high-, moderate-, and low-BMI) and overweight/obesity at 4 years were the childhood outcomes of interest. Differentially expressed genes (DEGs) associated with the outcomes were identified using DESeq2. Pathway enrichment analysis was performed on DEGs. Their causal relationships with outcomes were explored using the Mendelian randomization (MR) approach.

resultsWe identified 22 and 23 DEGs associated with BMI trajectories and overweight/obesity, respectively, with false discovery rates (FDR) < 0.05. Pathway analysis of these DEGs identified 26 biological pathways, primarily related to the immune system. MR analysis suggested that one (SSX2B) and eight DEGs (e.g., HSPA1A, DNAJB1) might be causally associated with the BMI trajectories and overweight/obesity (FDR < 0.05), respectively.

conclusionsThis study identified placental gene expression associated with early childhood growth outcomes. These findings suggest the potential important role of placental immune system genes in the development of childhood obesity.

Indexed as

Child DevelopmentPediatric ObesityPlacentaBody Mass IndexChild, PreschoolFemaleGene ExpressionHumansInfantInfant, NewbornMaleMendelian Randomization AnalysisPregnancyRisk FactorsTranscriptomechildhood obesitygrowth trajectoryplacentatranscriptome

Identifiers

PMID40709507
PMCPMC12313268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.