Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jinxi WangAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0002-7349-6153
Daniela Sarahi Yang BennettAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0009-0006-3085-1596
Emma J EchardAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).
Biyi ChenAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0003-0402-7537
Grace CiampaDepartment of Biochemistry and Molecular Biology (G.C., L.-S.S.), Carver College of Medicine, University of Iowa, Iowa City, IA.ORCID 0000-0001-5418-996X
Weiyang ZhaoAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0001-5707-376X
Qian ShiAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0003-2634-9553
Jin-Young YoonAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0002-5707-3636
Robert M WeissAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0003-1307-2647
Chad E GrueterAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0001-8950-742X
Duane D HallAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0003-2228-0966
Barry LondonAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0003-1506-3947
Long-Sheng SongAbboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine (J.W., D.S.Y.B., E.J.E., B.C., W.Z., Q.S., J.-Y.Y., R.M.W., C.E.G., D.D.H., B.L., L.-S.S.).ORCID 0000-0002-6035-8106
Funding
Novel Functions of the E-C Coupling Structural Protein Junctophilin-2 in the HeartR01HL130346 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2016 to 2023
$4.4M
ERK1/2-Integrin Signaling in Desmosome-Dyad CrosstalkR01HL157741 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2021 to 2024
$2.5M
Propagation and Resolution of Injury in Calcific Aortic Valve DiseaseR01HL142935 · NHLBI · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2018 to 2022
$2.3M
Molecular Determinants of MG53 in Heart Structure and FunctionR01HL157781 · NHLBI · UNIVERSITY OF IOWA · PI SONG, LONG-SHENG · 2021 to 2024
$2.2M
Hydrogel matrices to study the role of inflammation and biological sex on aortic valve fibrocalcificationR01HL171197 · NHLBI · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, ROBERT M WEISS · 2024 to 2026
$2.0M
Junctophilin-1 in the heartR01HL176940 · NHLBI · UNIVERSITY OF IOWA · PI Long-Sheng Song · 2025 to 2026
$1.4M
Junctophilin-2 in Cardiac FibroblastsR01HL181428 · NHLBI · UNIVERSITY OF IOWA · PI Long-Sheng Song · 2025 to 2026
$1.3M
High Resolution Research UltrasoundS10OD038119 · OD · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2025 to 2025
$419k
High-Resolution Research UltrasoundS10OD019941 · OD · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2015 to 2015
methodsJunctophilin expression was assayed in human and mouse CFs using reverse transcription quantitative polymerase chain reaction, Western blotting, and immunofluorescence. To investigate the functional role of Jph2 in CFs, we assessed Ca
resultsJph2 was identified as the only junctophilin expressed in CFs and acutely upregulated in response to myocardial infarction. Cellular and RNA sequencing analyses revealed that isolated Jph2-deficient CFs exhibited impaired fibroblast activation, reduced extracellular matrix production, and diminished expression of VEGFA (vascular endothelial growth factor A), VEGFB, and VEGFC after TGFβ treatment. In vivo, Jph2
conclusionsOur results demonstrate that Jph2 is required in CFs to orchestrate Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Junctophilin-2 Regulates Store-Operated Calcium Entry to Drive Cardiac Fibroblast Activation, Fibrotic Repair, and Angiogenesis After Myocardial Infarction. · full record | OpenQuestion