ArticleMolecular medicine reports2025
SIRT5 is associated with asthenozoospermia and regulates GC‑2 spd cell proliferation and apoptosis.
Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring cadmium exposure as a contributor to male infertility: insights from the relationship between environmental pollutants and the male reproductive system.Frontiers in endocrinology · 2026Pooled it
- Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a multifactorial condition that affects ~7% of the male population. The mechanism of male infertility primarily involves intrinsic and environmental factors, of which genetic defects are key for its occurrence. Sirtuin 5 (SIRT5) is primarily localized in mitochondria and associated with male reproduction. SIRT5 is downregulated in asthenozoospermic sperm compared with normal sperm. To explore the role of SIRT5 in male reproduction, Cell Counting Kit‑8, EdU, wound healing, and apoptosis assayswere performed in GC‑2 spd cells (mouse spermatocytes) which revealed that SIRT5 inhibited apoptosis and promoted cell proliferation and migration. Western blotting was performed and the results showed that SIRT5 was involved in the proliferation of GC‑2 spd cells by regulating the PI3K/AKT signaling pathway. The present study demonstrated a mechanism of male infertility, which may aid in its treatment.
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