Evidence map›Paper›PMID 40709277›Full record

ArticleResearch square2025

Composition of Carotid Plaques Differs Between Chinese and United States Patients: A Histology Study.

Jingli Cao, Marina Ferguson, Jie Sun, Mi Shen, Randy Small, Daniel S Hippe, Xihai Zhao, Dong Zhang, Hiroko Watase, Chun Yuan and 10 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Jingli CaoChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Marina FergusonVascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Jie SunVascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Mi ShenDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Randy SmallDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
Daniel S HippeFred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA.
Xihai ZhaoCenter for biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Dong ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, Beijing 100070, China.
Hiroko WataseDepartment of Surgery, University of Washington, Seattle, WA 98195, USA.
Chun YuanVascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Peiyi GaoDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
James Kevin DeMarcoThe Department of Radiology, Walter Reed National Military Medical Center, Uniformed Services University of Health Sciences, Bethesda, Maryland 20889, USA.
Roberto F NicosiaDepartment of Laboratory Medicine and Pathology, University of Washington.
Yajie WangDepartment of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Haowen LiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Zirui LiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yi WangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Ted KohlerDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, Beijing 100070, China.
Thomas HatsukamiDepartment of Surgery, University of Washington, Seattle, WA 98195, USA.
Binbin SuiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Funding

Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical SequelaeR01HL103609 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS, YUAN, CHUN · 2011 to 2021
$7.1M
Magnetic Resonance Imaging of Vulnerable PlaqueR01HL073401 · NHLBI · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS · 2003 to 2006
$2.3M
Culprit Plaque in Acute Cerebral Infarction: A Histological and MRI AssessmentR01NS083503 · NINDS · UNIVERSITY OF WASHINGTON · PI HATSUKAMI, THOMAS · 2013 to 2015
$598k
NHLBI NIH HHS R01 HL073401NHLBI NIH HHS R01 HL103609NINDS NIH HHS R01 NS083503
6 · The paper itself

Abstract

Background: The clinical manifestations of cerebrovascular disease are known to differ between the Chinese and United States (U.S.) populations as do the plaque features on imaging. Objectives: The aim of this study was to investigate and compare the histological features of excised carotid plaques from Chinese and U.S. patients. Methods: Carotid endarterectomy specimens collected from two prospective studies were included. The entire plaque was serially sectioned (10 μm thickness) at 0.5-1 mm intervals. Hematoxylin and eosin staining and Mallory's trichrome staining were performed. The morphology and components of the plaques were measured and compared between the two groups. Results: A total of 1,152 histological sections from 75 Chinese patients and 1,843 sections from 111 U.S. patients were analyzed. The Chinese group had significantly smaller minimum lumen diameters (median: 1.1 vs. 1.3 mm, p=0.046) and a larger percent wall volume (median: 74% vs. 70%, p=0.018) than the U.S. group. After adjusting for confounding factors, carotid plaques in the Chinese population were more likely to have more lipid pools (β=10.0%, 95%CI: 4.9 to 15.9%), more recent intraplaque hemorrhage (IPH; β=8.4%, 95%CI: 4.5 to 12.7%), and less late IPH (β=-8.2%, 95%CI: -11.3 to -5.4), and fewer fibrous cap disruptions (45% vs. 67%, p=0.061). Chinese plaques were more homogeneous and had a higher percentage of plaques with features of xanthomas than did U.S. plaques (20% vs 2.7%, p<0.001). Conclusions: The histology of Chinese plaques differs significantly from that of U.S. plaques, suggesting substantial differences in the pathophysiology of atherosclerotic cerebrovascular disease between Chinese and North American populations, which could enhance the gap in racial pathology comparison, indicating a need for a different management approach.

Indexed as

Atherosclerotic plaquesCarotid arteryCarotid endarterectomyHistology

Identifiers

PMID40709277
PMCPMC12288538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.