ArticleResearch square2025
Networked Salt-Bridges Mediate Magnesium-Dependent Conformational Dynamics and Functional Regulation in Type IA Topoisomerases.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Protein conformational dynamics are fundamental to enzyme function, yet the molecular mechanisms by which these dynamics are regulated remain poorly understood. Here, we reveal that a conserved network of salt-bridges, modulated by magnesium ions, serves as a key regulator of conformational transitions in Type IA topoisomerases (TopIA). Using a combination of molecular dynamics simulations, targeted protein mutagenesis, and functional assays, we demonstrate that Mg
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