ArticleResearch square2025
Age and Sex Moderate the Effects of Sleep Quality on Resting-State Functional Connectivity in the Salience and Default Mode Network.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Aging often coincides with declining sleep quality, which can contribute to cognitive decline and increased dementia risk. Neuroimaging offers valuable insights into how poor sleep may affect brain health before cognitive or behavioral changes appear. Given the different prevalence rates of dementia between sexes, sleep disturbances might uniquely impact females relative to males. The goal of this study was to investigate how age and sex moderate the impact of sleep quality on resting-state functional connectivity. Based on the extant literature, we predicted that sleep quality would significantly impact connectivity in the default mode network, salience network, and the amygdala. Adults (N = 95), aged 20-74, completed the Pittsburgh Sleep Quality Index and underwent two 5-min sessions of resting-state MRI. Three-way interactions between age, sex, and sleep quality were found between the default mode network and the left superior parietal lobule. A two-way interaction between age and sleep quality was found between the salience network and right precentral/postcentral gyrus. No relationships were found using the amygdala as a seed region. Furthermore, sleep consistently contributed to the sleep quality-connectivity effects found for young adults and multiple sleep components varied in older adults. The results suggest that poor sleep affects the salience networks in both males and females, with variations in adaptive patterns depending on age. The default mode network appears particularly sensitive to sleep impairments in females, consistent with early desegregation of brain networks and increased risk for dementia. The alterations in young adults support the hyperarousal hypothesis as a potential contributor to insomnia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.