Evidence map›Paper›PMID 40709071›Full record

ReviewHealth science reports2025

Remdesivir Versus Sotrovimab in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.

Saeed Khorramnia, Zia Navidi, Ali Sarkoohi, Mojgan Mohajeri Iravani, Amirhossein Orandi, Amirali Orandi, Samrand Fattah Ghazi, Ehsan Fallah, Ebadallah Shiri Malekabad, Seyed Hamid Pakzad Moghadam

Abstract readReview
In one paragraph

Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saeed KhorramniaDepartment of Anesthesiology, School of Medicine Rafsanjan University of Medical Sciences Rafsanjan Iran.
Zia NavidiDepartment of Anesthesiology, School of Medicine Rafsanjan University of Medical Sciences Rafsanjan Iran.
Ali SarkoohiDepartment of Anesthesiology, School of Medicine Rafsanjan University of Medical Sciences Rafsanjan Iran.
Mojgan Mohajeri IravaniSchool of Allied Medical Sciences, 503 Hospital (Hajar) AJA University of Medical Sciences Tehran Iran.
Amirhossein OrandiSchool of Medicine, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran.
Amirali OrandiDepartment of Anesthesia and Critical Care, Sina Hospital Tehran University of Medical Sciences Tehran Iran.
Samrand Fattah GhaziDepartment of Anesthesiology and Critical Care, School of Medicine, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran.
Ehsan FallahDepartment of Orthopedics, School of Medicine AJA University of Medical Sciences Tehran Iran.
Ebadallah Shiri MalekabadSchool of Nursing AJA University of Medical Sciences Tehran Iran.
Seyed Hamid Pakzad MoghadamDepartment of Anesthesiology, School of Medicine Rafsanjan University of Medical Sciences Rafsanjan Iran.ORCID https://orcid.org/0000-0002-5456-0017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Remdesivir and Sotrovimab have emerged as potential treatment options for patients diagnosed with coronavirus disease 2019 (COVID-19). This systematic review and meta-analysis sought to evaluate and compare the effectiveness and safety of these two drugs in the context of COVID-19 management. Methods: A systematic search was conducted in PubMed, Cochrane Library, Web of Science, medRxiv, and Google Scholar up to July 2024. The effectiveness outcomes examined included mortality rate, hospitalization rate, emergency department visits, ICU admission, and adverse events. The risk of bias in nonrandomized studies of interventions was evaluated using a standardized tool, and data from the identified studies were meticulously analyzed using Comprehensive Meta-Analysis (CMA) software. Results: The analysis incorporated a total of 9 studies involving 7841 patients. The meta-analysis findings indicated no significant disparity between the Remdesivir and Sotrovimab groups concerning mortality rate (odds ratio [OR] = 3.49, 95% confidence interval [CI]: 0.50-24.11, Conclusion: The study findings suggest that there is no significant difference in effectiveness between Remdesivir and Sotrovimab in the treatment of COVID-19 patients. Further research is needed to provide a more comprehensive comparison of these interventions for COVID-19.

Indexed as

COVID‐19effectivenessRemdesivirsafetySARS‐CoV‐2Sotrovimab

Identifiers

PMID40709071
PMCPMC12287540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.