Evidence map›Paper›PMID 40709067›Full record

ArticleFrontiers in allergy2025

The chronological age at which small airway function starts to decline in a healthy Chinese population: a cross-sectional study.

Lili Hou, Yonglu Guo, Yurong Zhang, Zhenghua Zhu, Ningfang Lian, Ying Gong, Bairong Du, Yuanyuan Liu, Jichen Qu, Xian Zhu and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Small airways dysfunction: associated factors, clinical aspects and new perspectives.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lili Hou *Department of Respiratory and Critical Care Medicine, Jiuquan Branch of Shanghai General Hospital, Gansu, China.
Yonglu Guo *Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yurong Zhang *Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhenghua Zhu *Department of Otolaryngology, Jiuquan Branch of Shanghai General Hospital, Gansu, China.
Ningfang LianDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Institute of Respiratory Disease, Fujian Medical University, Fujian, China.
Ying GongDepartment of Respiratory and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Bairong DuDepartment of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuanyuan LiuDepartment of Respiratory and Critical Care Medicine, Dunhuang General Hospital, Dunhuang, China.
Jichen QuDepartment of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xian ZhuDepartment of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lei ZhuDepartment of Critical and Pulmonary Medicine, Huadong Hospital, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Small airway function naturally declines with aging. However, the precise age this decline begins in healthy Chinese individuals remains unclear. This study aimed to identify the chronological age at which small airway dysfunction (SAD) initiates and its predictors within a healthy Chinese population. Methods: We conducted a retrospective, cross-sectional, multicenter analysis of 462 adults undergoing routine health checkups. The participants underwent standard spirometry and completed questionnaires. The onset age of SAD was determined using the area under the receiver operating characteristic curves (AUCs). Univariate and multivariate analyses identified relationships between variables and SAD. Results: Healthy individuals aged 55 years or older demonstrated SAD. Age was an important independent predictor for SAD (odds ratio, 1.107; Conclusion: We identified SAD predictors in a healthy Chinese population with environmental exposure. An age of 55 years or older was the threshold for predicting SAD in these healthy participants.

Indexed as

agingsmall airwaysmall airway dysfunctionspirometrythe area under receiver operating characteristic curves

Identifiers

PMID40709067
PMCPMC12287095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.